Abstract
Vitamin D (Vit D) is an essential element for the regulation of serum calcium, phosphate, and alkaline phosphatase (Alk Ph). Because the Vit D serum level is not usually measured directly, Vit D deficiency is diagnosed indirectly by changes in serum calcium, phosphate, and Alk Ph leves. The current study assessed the status of these biochemical parameters in subjects with different degrees of Vit D deficiency. We selected 1,210 subjects, between 20 and 69 years old, randomly from the Tehran population. Subjects with diseases or medications that modified bone metabolism were excluded from the study. Serum 25(OH) D, calcium, phosphate, Alk Ph, and parathyroid hormone (PTH) levels were measured and the status of these biochemical parameters was compared in subjects with different degrees of Vit D deficiency. Vit D deficiency was diagnosed in 79.6% of the subjects. Different degrees of Vit D deficiency were classified as follows: group 1, severe; group 2, moderate; and group 3, mild. Serum PTH levels in the Vit D-deficient groups were significantly higher than that in group 4 (normal Vit D). Serum calcium and phosphate levels in groups 1 and 2 were significantly lower than those in groups 3 and 4. No significant difference was seen...Continue Reading
References
May 29, 1976·Lancet·K M GoelR A Shanks
Apr 1, 1990·Clinical Science·J A NisbetJ D Maxwell
Dec 1, 1985·The Biochemical Journal·J R McDonaldC M Kay
Apr 28, 1973·Lancet·M A PreeceJ L O'Riordan
Dec 1, 1967·Annals of Internal Medicine·A R ArnsteinH M Frost
Aug 1, 1984·Pediatric Research·S A TahaS H Sedrani
Sep 1, 1984·Postgraduate Medical Journal·V FonsecaH Abu-Aisha
Jul 1, 1983·The American Journal of Clinical Nutrition·S H SedraniK M El Arabi
Jan 1, 1984·Annals of Nutrition & Metabolism·S H Sedrani
Nov 1, 1982·The American Journal of Clinical Nutrition·A M ParfittG D Whedon
Jun 1, 1982·Journal of Clinical Pathology·H PeachL W Horton
Dec 1, 1982·The American Journal of Clinical Nutrition·J L OmdahlJ S Goodwin
Nov 1, 1993·The American Journal of Medicine·C T Bingham, L A Fitzpatrick
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M C ChapuyP J Meunier
Mar 20, 1998·The New England Journal of Medicine·R D Utiger
Mar 31, 1998·Lancet·A MalabananM F Holick
Jul 4, 1998·Lancet·N SattarI A Greer
Aug 8, 1998·The New England Journal of Medicine·A C Looker, E W Gunter
Mar 25, 1999·Calcified Tissue International·S T HadenM S LeBoff
May 5, 1999·JAMA : the Journal of the American Medical Association·M S LeBoffJ Glowacki
Jul 23, 1999·BioFactors·J G ErikssonM Rohde
May 10, 2000·Journal of Endocrinological Investigation·F AlagölO Sandalci
Jun 6, 2000·The American Journal of Clinical Nutrition·A G NeedB C Nordin
Feb 22, 2001·Endocrinology·S GallinatC Sumners
Aug 9, 2001·Endocrine Reviews·P Lips
Jan 10, 2002·Infectious Disease Clinics of North America·R R Magadia, M P Weinstein
Citations
Jun 23, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A MithalUNKNOWN IOF Committee of Scientific Advisors (CSA) Nutrition Working Group
Jun 8, 2011·Journal of Immigrant and Minority Health·L PetersonK Schwartz
Dec 12, 2012·Archives of Osteoporosis·D A WahlB Dawson-Hughes
Aug 10, 2010·Irish Journal of Medical Science·G O'Malley, E Mulkerrin
Aug 18, 2010·Irish Journal of Medical Science·E LardnerE Mulkerrin
Jul 11, 2006·Nederlands tijdschrift voor geneeskunde·Tj WiersmaD O A Daemers
Feb 19, 2008·The British Journal of Nutrition·Rosa M OrtegaPedro Andrés
May 21, 2008·Orphanet Journal of Rare Diseases·Claudia E Dumitrescu, Michael T Collins
Jan 1, 2012·Journal of Diabetes and Metabolic Disorders·Ehsaneh TaheriManouchehr Madani Civi
Mar 30, 2012·PloS One·Adil SheikhSyed Ather Hussain
Mar 8, 2013·Public Health Nutrition·Jamal GolbaharGhada Al-Kafaji
Aug 13, 2013·The British Journal of Nutrition·Jennifer HilgerKristina Hoffmann
Dec 7, 2013·World Journal of Surgery·P V Pradeep, K Ramalingam
Oct 17, 2013·Aging Clinical and Experimental Research·Walaa W AlyAhmed K Mortagy
Oct 2, 2013·Indian Journal of Endocrinology and Metabolism·M K GargNamita Mahalle
Aug 16, 2016·Revista Brasileira De Ortopedia·Patricia KhashayarBagher Larijani
Sep 12, 2008·Best Practice & Research. Clinical Rheumatology·Rohini HandaGhassan Maalouf
Jan 31, 2009·Obesity·Elena Rodríguez-RodríguezRosa M Ortega
May 21, 2013·Clinical Endocrinology·M K GargN Mahalle
Jul 15, 2015·Journal of the American College of Nutrition·Hanieh-Sadat EjtahedFereidoun Azizi
Mar 15, 2005·BMC Endocrine Disorders·Alireza MoayyeriBagher Larijani
Nov 7, 2013·Dermato-endocrinology·Darina BassilGhada El-Hajj Fuleihan
Jun 15, 2011·Metabolism: Clinical and Experimental·Agustina AlonsoUNKNOWN Collaborative Group on Prophylaxis with Vitamin D in Asturias
Aug 20, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·María Agustina AlonsoFernando Santos
Aug 24, 2016·Geriatric Orthopaedic Surgery & Rehabilitation·Osama FaroukAzza Ez-Eldeen
May 1, 2018·Archives of Osteoporosis·AlJohara M AlQuaizNada Alyousefi
Feb 8, 2019·Indian Journal of Clinical Biochemistry : IJCB·Joseph Dian BonduJude Joseph Fleming
Dec 17, 2020·Curēus·Abdul Wali KhanAmber Tahir
Sep 9, 2019·International Journal of Surgery·Mehreen Khan BhettaniKamran Hakeem Khan