The status of olfactory function and the striatal dopaminergic system in drug-induced parkinsonism.

Journal of Neurology
Tommaso BoviMichele Tinazzi

Abstract

Olfactory impairment has been reported in drug-induced parkinsonism (DIP), but the relationship between dopaminergic dysfunction and smell deficits in DIP patients has not been characterized. To this end, we studied 16 DIP patients and 13 patients affected by Parkinson's disease (PD) using the "Sniffin' Sticks" test and [(123)I] FP-CIT SPECT (single-photon emission computed tomography). DIP patients were divided based on normal (n = 9) and abnormal (n = 7) putamen dopamine transporter binding. Nineteen healthy age- and sex-matched subjects served as controls of smell function. Patients with DIP and pathological putamen uptake had abnormal olfactory function. In this group of patients, olfactory TDI scores (odor threshold, discrimination and identification) correlated significantly with putamen uptake values, as observed in PD patients. By contrast, DIP patients with normal putamen uptake showed odor functions-with the exception of the threshold subtest-similar to control subjects. In this group of patients, no significant correlation was observed between olfactory TDI scores and putamen uptake values. The results of our study suggest that the presence of smell deficits in DIP patients might be more associated with dopaminergic ...Continue Reading

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Jun 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·R J Hardie, A J Lees
Sep 28, 1998·Annals of Neurology·D J Brooks
Jun 27, 2000·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·G KobalT Hummel
Feb 24, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·G TissinghE C Wolters
Oct 18, 2002·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·A MüllerT Hummel
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Oct 8, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Eduardo TolosaMarisol Gallardo
Jun 16, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Evelien HuismanPiet V Hoogland
Oct 27, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Mordechai LorberboymRuth Djaldetti
Jun 10, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Antje MuellerThomas Hummel
Oct 6, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·T HummelA Mackay-Sim
May 18, 2007·Journal of Neurology·Nicolaas I BohnenRobert Y Moore
Jun 15, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Phil Hyu LeeYun Joong Kim
Sep 2, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Michele TinazziAngelo Antonini
Sep 2, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Sanne BoesveldtHenk W Berendse
Sep 5, 2008·Journal of Neurology·Stephanie KrügerThomas Hummel
Jan 14, 2009·Parkinsonism & Related Disorders·A HaehnerT Hummel
Mar 3, 2009·Journal of Neurology·Michele TinazziSarah Ottaviani
Apr 15, 2009·Current Treatment Options in Neurology·Frandy Susatia, Hubert H Fernandez

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Citations

Feb 21, 2014·Acta Neuropathologica·Johannes AttemsKurt A Jellinger
Dec 24, 2011·Neurobiology of Disease·Richard L Doty
Dec 22, 2010·Neurologic Clinics·Stanley N CaroffE Cabrina Campbell
May 28, 2011·Depression and Anxiety·Cinto SegalàsJosé M Menchón
Sep 23, 2014·Early Intervention in Psychiatry·Julia H MeijerUNKNOWN Genetic Risk and Outcome of Psychosis (GROUP) Study
Apr 20, 2014·Parkinsonism & Related Disorders·James F MorleyJohn E Duda
Aug 16, 2016·The Psychiatric Clinics of North America·Stanley N Caroff, E Cabrina Campbell
Jan 27, 2017·Journal of Movement Disorders·Seung Ha LeeMyung Sik Lee
May 1, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Manon GaloppinPierre J Blanchet
Aug 24, 2017·Neuroscience Bulletin·Michelle E FullardJohn E Duda
Feb 7, 2021·Expert Review of Neurotherapeutics·Cintia C G AlonsoSandra M S F Freitas
Nov 25, 2020·Rinshō shinkeigaku = Clinical neurology·Yasushi Shimo, Nobutaka Hattori
Jul 31, 2021·Journal of Neural Transmission·Maria Paola CecchiniStefano Tamburin

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