The status of radioimmunotherapy in CD20+ non-Hodgkin's lymphoma

Targeted Oncology
Evan D ReadTerrence J Piva

Abstract

Rituximab, the CD20-directed antibody, has become a standard component of treatment regimens for patients with B cell non-Hodgkin's lymphoma (NHL). The use of rituximab has resulted in greatly improved response and survival rates with less toxicity relative to standard chemotherapeutic regimes. However, relapse and recurrence is common, particularly in indolent varieties which remain incurable, requiring alternate therapeutic options. The subsequent coupling of β-emitting isotopes such as (131)I and (90)Y to anti-CD20 monoclonal antibodies (mAbs), including rituximab, has been steadily growing over the last decade and demonstrates even greater therapeutic efficacy with more durable responses. (177)Lutetium-labelled rituximab offers a number of convenient advantages over (131)I and (90)Y anti-CD20 mAbs for treatment of NHL, and a number of alpha-emitting isotopes lie at the frontier of consolidation therapy for residual, micrometastatic disease.

References

Sep 1, 1989·Medical Toxicology and Adverse Drug Experience·A Slikkerveer, F A de Wolff
Dec 13, 1984·Nature·G L BoulianneM J Shulman
Aug 12, 1993·The New England Journal of Medicine·Mark S KaminskiG M Butchko
Aug 15, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P McLaughlinB Dallaire
Sep 2, 1998·European Journal of Nuclear Medicine·Michael R McDevittDavid A Scheinberg
Apr 24, 1999·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Michael R McDevittDavid A Scheinberg
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Myron S CzuczmanC Varns
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonG P Canellos
Mar 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie M VoseMark S Kaminski
Feb 7, 2001·Cancer Immunology, Immunotherapy : CII·D ShanOliver W Press
Jul 21, 2000·Current Pharmaceutical Design·Michael R Zalutsky, Ganesan Vaidyanathan
Aug 30, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T A DavisR Levy
Sep 6, 2000·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·N A LebedevF Rösch
Sep 8, 2001·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·D MaDavid A Scheinberg
Sep 28, 2001·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·D MaDavid A Scheinberg
Nov 17, 2001·Science·Michael R McDevittDavid A Scheinberg
Aug 30, 2002·Leukemia·L E van der KolkE Eldering
Oct 31, 2002·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Michael R McDevittDavid A Scheinberg
Sep 19, 2003·Seminars in Nephrology·Eric P Cohen, Mike E C Robbins
Jun 3, 2004·The Lancet Oncology·Bryan T HennessyPeter A Daly
Jul 28, 2004·International Journal of Radiation Oncology, Biology, Physics·M Carmen Hernandez, Susan J Knox
Oct 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Myron S CzuczmanA J Grillo-López
Dec 4, 2004·Nuclear Medicine Communications·Katia VandenbulckeGuido Slegers
Jan 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E WitzigDebra A Welker
Feb 4, 2005·The New England Journal of Medicine·Mark S KaminskiRichard L Wahl
Mar 15, 2005·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Rose A BollSaed Mirzadeh
May 4, 2005·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·E P HorwitzJ M Williamson
Jun 7, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Maren BienertDieter L Munz
Jul 1, 2005·Journal of the American Society of Nephrology : JASN·Jaspreet Singh JaggiDavid A Scheinberg
Aug 16, 2005·Seminars in Nuclear Medicine·Gerald DeNardo
Sep 10, 2005·Nature Biotechnology·Nils Lonberg
Dec 3, 2005·Cancer Biology & Therapy·Barry J AllenJohn Kearsley
Aug 31, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael F LeahyJ Harvey Turner
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Oyvind S BrulandRoy H Larsen
Jul 27, 2007·Cancer Biotherapy & Radiopharmaceuticals·Roy H LarsenOyvind S Bruland
Oct 9, 2007·Nuclear Medicine and Biology·C Andrew Boswell, Martin W Brechbiel
Oct 19, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Heather A JaceneRichard L Wahl
Nov 21, 2007·Hematology·Celeste Bello, Eduardo M Sotomayor
Jan 16, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Pier Luigi ZinzaniAchiel Van Hoof
Jan 29, 2008·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Kamalika Roy, Susanta Lahiri
Jun 3, 2008·Advanced Drug Delivery Reviews·Matthias MiedererMichael R McDevitt
Jun 11, 2008·Advanced Drug Delivery Reviews·George Sgouros
Feb 27, 2009·Cancer Biotherapy & Radiopharmaceuticals·Ly TranAlwin D R Huitema
Apr 8, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Flavio ForrerHelmut R Maecke
Aug 15, 2009·International Journal of Radiation Oncology, Biology, Physics·Jostein DahleYngve Kvinnsland
Oct 20, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Angelika Bischof DelaloyeAnton Hagenbeek
Sep 1, 2008·Current Radiopharmaceuticals·Ganesan Vaidyanathan, Michael R Zalutsky
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Apr 9, 2011·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Paola F AudicioPatricia Oliver
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hendrik NogaiGeorg Lenz
Jun 11, 2011·Best Practice & Research. Clinical Haematology·E LeichA Rosenwald
Jun 11, 2011·Best Practice & Research. Clinical Haematology·Izidore S Lossos, Randy D Gascoyne
Jun 11, 2011·Best Practice & Research. Clinical Haematology·Marinus H J van Oers, Marie José Kersten
Jun 11, 2011·Best Practice & Research. Clinical Haematology·Andrew R Rezvani, D G Maloney
Dec 29, 2011·Current Radiopharmaceuticals·Michael R Zalutsky, Marek Pruszynski
Dec 29, 2011·Current Radiopharmaceuticals·Nicolas Chouin, Manuel Bardies
Dec 29, 2011·Current Radiopharmaceuticals·David A Scheinberg, Michael R McDevitt
Jan 24, 2013·Current Topics in Medicinal Chemistry·Sandrine Huclier-MarkaiJacques Barbet
Apr 11, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Flavio ForrerAndreas Lohri
May 15, 2013·Translational Behavioral Medicine·Daniela P LadnerMichael M Abecassis
Sep 5, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michel ChérelFrançois Davodeau
Mar 8, 2014·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Partha Sarathi RoyReena Nair

Related Concepts

Rituximab
Antineoplastic Agents
Reticulosarcoma
Radioimmunotherapy
Molecular Targeted Therapy
Monoclonal Antibodies
Isotope Labeling
Isotopes
Lymphoma, Non-Hodgkin
Treatment Protocols

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.