The status of strontium in biological apatites: an XANES/EXAFS investigation

Journal of Synchrotron Radiation
Dominique BazinMichel Daudon

Abstract

Osteoporosis represents a major public health problem through its association with fragility fractures. The public health burden of osteoporotic fractures will rise in future generations, due in part to an increase in life expectancy. Strontium-based drugs have been shown to increase bone mass in postmenopausal osteoporosis patients and to reduce fracture risk but the molecular mechanisms of the action of these Sr-based drugs are not totally elucidated. The local environment of Sr(2+) cations in biological apatites present in pathological and physiological calcifications in patients without such Sr-based drugs has been assessed. In this investigation, X-ray absorption spectra have been collected for 17 pathological and physiological calcifications. These experimental data have been combined with a set of numerical simulations using the ab initio FEFF9 X-ray spectroscopy program which takes into account possible distortion and Ca/Sr substitution in the environment of the Sr(2+) cations. For selected samples, Fourier transforms of the EXAFS modulations have been performed. The complete set of experimental data collected on 17 samples indicates that there is no relationship between the nature of the calcification (physiological an...Continue Reading

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Sep 4, 2015·Nature Reviews. Urology·Krishna RamaswamyMarshall L Stoller
Jul 30, 2016·Progress in Biomaterials·Sergey V Dorozhkin
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May 20, 2017·Scientific Reports·Yurina SekineKazunari Akiyoshi
May 28, 2019·Acta Biomaterialia·Camila Bussola TovaniNadine Nassif

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