The status of the precommissural and postcommissural fornix in normal ageing and mild cognitive impairment: An MRI tractography study

NeuroImage
Kat ChristiansenClaudia Metzler-Baddeley

Abstract

The fornix connects the hippocampal formation with structures beyond the temporal lobe. Previous tractography studies have typically reconstructed the fornix as one unified bundle. However, the fornix contains two rostral divisions: the precommissural fornix and the postcommissural fornix. Each division has distinct anatomical connections and, hence, potentially distinct functions. Diffusion weighted MRI and spherical deconvolution based tractography were employed to reconstruct these separate fornix divisions and to examine their microstructural properties in both healthy ageing and Mild Cognitive Impairment (MCI). Reliable reconstructions of precommissural and postcommissural fibres were achieved in both groups, with their fibres retaining largely separate locations within the anterior body of the fornix. Ageing and MCI had comparable effects on the two segments. Ageing was associated with changes in mean, axial and radial diffusivity but not with alterations of fibre population-specific diffusion properties, estimated with the hindrance modulated orientational anisotropy (HMOA). Individual HMOA variation in postcommissural, but not precommissural, fibres correlated positively (and unrelated to age) with visual recall perform...Continue Reading

References

Sep 1, 1977·The Journal of Comparative Neurology·C E Poletti, G Creswell
Aug 1, 1995·Neurology·M D'EspositoD I Katz
Mar 1, 1994·Journal of Magnetic Resonance. Series B·P J BasserD LeBihan
Dec 25, 1995·The Journal of Comparative Neurology·S T Carmichael, J L Price
Dec 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C Pierpaoli, P J Basser
Dec 31, 1997·Journal of Clinical and Experimental Neuropsychology·E GroberR B Lipton
Feb 14, 1998·Neurobiology of Aging·Y TangH J Gundersen
Dec 9, 1998·Journal of Clinical and Experimental Neuropsychology·C RandolphT N Chase
May 14, 1999·Current Opinion in Neurobiology·M G Baxter, A A Chiba
Sep 1, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D K JonesA Simmons
Apr 17, 2001·The Behavioral and Brain Sciences·J P Aggleton, M W Brown
May 4, 2001·Brain : a Journal of Neurology·P C Fletcher, R N Henson
Aug 2, 2003·Nature Reviews. Neuroscience·Jon S Simons, Hugo J Spiers
Sep 1, 1953·Brain : a Journal of Neurology·H DAITZ
Jan 7, 2004·Nature Reviews. Neuroscience·Seralynne D Vann, John P Aggleton
Nov 26, 2005·The European Journal of Neuroscience·John P AggletonRichard C Saunders
Dec 22, 2005·The European Journal of Neuroscience·Philip G F BrowningDavid Gaffan
Mar 21, 2007·Hippocampus·Richard C Saunders, John P Aggleton
Jun 17, 2008·Nature Neuroscience·Dimitris TsivilisJohn P Aggleton
Jul 23, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ofer PasternakYaniv Assaf
Nov 17, 2009·Brain : a Journal of Neurology·Julio Acosta-CabroneroPeter J Nestor
Nov 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah R RudebeckAndy C H Lee
Feb 16, 2010·Neuron·Michael S Fanselow, Hong-Wei Dong
Oct 5, 2010·NMR in Biomedicine·Derek K Jones, Mara Cercignani
Sep 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Claudia Metzler-BaddeleyMichael J O'Sullivan
Sep 20, 2011·NeuroImage·Claudia Metzler-BaddeleyDerek K Jones
Nov 22, 2011·Acta Neuropathologica·Elliott J MufsonStephen W Scheff
Aug 14, 2012·Neuropsychologia·Alexander EastonColin Lever
Nov 24, 2012·Neurology·Claudia Metzler-BaddeleyMichael J O'Sullivan
Feb 1, 2013·Yonsei Medical Journal·Sang Seok YeoSung Ho Jang
Sep 23, 2014·Nature Reviews. Neuroscience·Bryan A StrangeEdvard I Moser
Sep 30, 2014·Neuroscience and Biobehavioral Reviews·Giovanni Augusto CarlesimoFrancesco Barban
Jan 16, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicola J RayMichael J O'Sullivan

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Citations

Jan 31, 2019·Psychological Medicine·Karen González-MadrugaGraeme Fairchild
May 24, 2019·Surgical and Radiologic Anatomy : SRA·José Pedro LavradorLia Neto
Sep 26, 2017·Brain and Neuroscience Advances·Emma J BubbJohn P Aggleton
Sep 25, 2019·The International Journal of Neuroscience·Viviana Lo BuonoSilvia Marino
Mar 29, 2020·Brain and Neuroscience Advances·Bethany M CoadClaudia Metzler-Baddeley
Jul 7, 2020·Frontiers in Human Neuroscience·Masaki TanakaSeiki Konishi
Apr 8, 2020·Neuropsychologia·Angharad N WilliamsCarl J Hodgetts
Aug 19, 2020··Zhi-Yuan Jin, Zhi-Yuan Jin

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