PMID: 2123729Aug 20, 1990Paper

The steady-state amino acid fluxes across the perfused choroid plexus of the sheep

Brain Research
J E Preston, M B Segal

Abstract

The steady-state flux of labelled amino acids was investigated across the isolated perfused choroid plexus of the sheep. The extraction of anionic, cationic, small and large neutral amino acids by the blood side of the choroid plexus was demonstrated. However, there was no uptake of the analogue MeAIB, confirming the absence of the 'A' carrier system on this side of the blood--CSF barrier. The direction of the net flux of amino acids across the tissue varied depending on the amino acid and its concentration. At a concentration of 0.01 mM the net movement for phenylalanine, serine, aspartate and glycine was from blood to CSF. When the concentration of amino acid was increased to 0.1 mM, the net flux of phenylalanine and serine remained from blood to CSF whereas the net flux of the transmitters, aspartate and glycine, was in the opposite direction, from CSF to blood. When the level was raised further, to 1 mM, all four amino acids showed a net CSF to blood flux. The concentration of amino acids is newly formed CSF was calculated from the blood to CSF fluxes and was found to be between 2 and 200 microM, similar to that found in mammalian bulk phase CSF.

References

Feb 1, 1975·Journal of Neurochemistry·G M FranklinR W Cutler
Jan 1, 1989·The Journal of Physiology·J E PrestonB V Zlokovic
May 1, 1985·The Journal of Physiology·R Deane, M B Segal
May 1, 1972·Journal of Applied Physiology·M PollayR Kaplan
Jul 9, 1971·Brain Research·L A CobenB Becker
Dec 1, 1971·The American Journal of Physiology·W H Oldendorf
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Dec 1, 1970·The Journal of Membrane Biology·J W Prather, E M Wright

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Citations

Jan 1, 1993·Journal of Inherited Metabolic Disease·M B Segal
Aug 18, 1997·Brain Research. Developmental Brain Research·H al-SarrafM B Segal
Apr 26, 2003·Journal of Toxicology and Environmental Health. Part a·Wei ZhengMalcolm B Segal
Aug 5, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ruo L ChenJane E Preston
Sep 13, 2003·Journal of Neurochemistry·Miroslav GottliebVivian I Teichberg
May 20, 2011·Journal of Neurochemistry·Yasuyuki KasaiKen-ichi Hosoya
Mar 20, 2010·Journal of Neurochemistry·Ruo-Li ChenJane Elizabeth Preston
Jan 3, 2001·Microscopy Research and Technique·M B Segal
Aug 5, 1998·The American Journal of Physiology·A ChodobskiM J McKinley
Oct 18, 2020·Pharmaceutics·Mark A BryniarskiMarilyn E Morris
Jul 13, 1994·Biochimica Et Biophysica Acta·S J ChungC M Brett

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