The steady-state pharmacokinetics and bioequivalence of carprofen administered orally and subcutaneously in dogs

Journal of Veterinary Pharmacology and Therapeutics
T P ClarkM G Boy

Abstract

Eighteen male Beagle dogs were randomized to oral (p.o.) or subcutaneous (s.c.) carprofen administration in a two-sequence, two-period crossover design with a 10-day washout between periods. Twenty-five milligrams of carprofen was administered p.o. or s.c. every 12 h for 7 days. Plasma concentrations of carprofen collected after the first and last treatments were determined by high-performance liquid chromatography. Carprofen concentration data were natural log transformed and geometric means were calculated for maximum plasma concentration (Cmax) and area under the plasma concentration-time curve (AUC0--12) following the first dose and Cmax and AUC0--12 following administration of the last dose. Formulations were considered bioequivalent if the 90% confidence interval (CI) of the mean difference for each variable between formulations were within -20% and 25% of the oral formulation. The mean Cmax and AUC0--12 were 16.9 microg/mL and 73.1 microg. h/mL, respectively, following a single oral dose and 8.0 microg/mL and 64.3 microg x h/mL, respectively, following a single s.c. injection. The 90% CI for Cmax (-56.8 to -48.7%) was outside of the bioequivalence criteria whereas the 90% CI for AUC0--12 (-16.3 to -7.5%) was within the b...Continue Reading

References

Oct 1, 1990·Biopharmaceutics & Drug Disposition·M Schmitt, T W Guentert
Oct 1, 1989·Journal of Cardiovascular Pharmacology·S A MousaP B Timmermans
Jun 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·J G OwensS A Barker
Dec 1, 1994·Journal of Veterinary Pharmacology and Therapeutics·Q A McKellarP Lees
Apr 1, 1997·Journal of Veterinary Pharmacology and Therapeutics·P L Toutain, G D Koritz
Aug 1, 1997·The Journal of Investigative Dermatology. Symposium Proceedings·T BiroP M Blumberg
Nov 27, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M Pairet, J van Ryn
Jun 9, 2001·Veterinary Ophthalmology·S.G. KrohneJ.R. Gionfriddo
Nov 6, 2001·Journal of the American College of Cardiology·T P Abraham, R A Nishimura

❮ Previous
Next ❯

Citations

Dec 18, 2013·BMC Veterinary Research·Elisabeth C JeunessePierre-Louis Toutain
Apr 3, 2007·American Journal of Veterinary Research·Marja R RaekallioS Marikki Peltoniemi
Feb 5, 2008·American Journal of Veterinary Research·Catherine A BriereRebecca S McConnico
Aug 27, 2013·Journal of the American Veterinary Medical Association·Rae G HutchinsShelly L Vaden
Sep 21, 2006·The Veterinary Clinics of North America. Small Animal Practice·Terrence P Clark
Aug 13, 2004·Journal of Veterinary Pharmacology and Therapeutics·J SteffanA Rohlfs
Apr 25, 2007·Veterinary Anaesthesia and Analgesia·B Duncan X LascellesSheilah A Robertson
Sep 6, 2005·Journal of the American Animal Hospital Association·Stephen L CurryJames L Cook
Sep 3, 2020·Australian Veterinary Journal·T H MorrisS L Karamatic

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
M C DumasiaE Houghton
The Journal of Surgical Research
Julio M MayolJesus A Fernandez-Represa
American Journal of Surgery
K KakizakiR Merrell
Journal of Veterinary Pharmacology and Therapeutics
P Lees
American Journal of Veterinary Research
Catherine A BriereRebecca S McConnico
© 2022 Meta ULC. All rights reserved