The Stepped Care Intervention to Suppress Viral Load in Youth Living With HIV: Protocol for a Randomized Controlled Trial

JMIR Research Protocols
Elizabeth Mayfield ArnoldAdolescent Medicine Trials Network CARES Team

Abstract

Among youth living with HIV (YLH) aged 12-24 years who have health care in the United States, only 30% to 40% are virally suppressed. YLH must achieve viral suppression in order to reduce the probability of infecting others as well as increasing the length and quality of their own life. This randomized controlled trial aimed to evaluate the efficacy of an Enhanced Standard Care condition (n=110) compared to an Enhanced Stepped Care intervention condition (n=110) to increase viral suppression among YLH aged 12-24 years with established infection (not acutely infected). YLH (N=220) who are not virally suppressed will be identified at homeless shelters, health clinics, and gay-identified community-based organizations in Los Angeles, CA, and New Orleans, LA. Informed consent will be obtained from all participants. YLH will be randomly assigned to one of two study conditions: Enhanced Standard Care, which includes standard clinical care plus an automated messaging and monitoring intervention (AMMI), or an Enhanced Stepped Care, which includes three levels of intervention (AMMI, Peer Support via social media plus AMMI, or Coaching plus Peer Support and AMMI). The primary outcome is viral suppression of HIV, and YLH will be assessed a...Continue Reading

Associated Clinical Trials

Apr 12, 2017·Mary Jane Rotheram-Borus

References

Jun 1, 1971·Journal of Abnormal Psychology·R M McFall, D B Lillesand
Dec 1, 1980·Journal of Consulting and Clinical Psychology·F M Gresham, R J Nagle
Nov 7, 1999·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·M E BelzerD J Tucker
Jul 6, 2000·Annals of Internal Medicine·D L PatersonN Singh
Jan 10, 2001·Annual Review of Psychology·L Steinberg, A S Morris
Feb 15, 2001·AIDS Care·D A MurphyUNKNOWN Adolescent Medicine HIV/AIDS Research Network
Jan 2, 2003·Journal of the American Medical Informatics Association : JAMIA·Peter J DunbarThomas M Hooton
Aug 3, 2005·Archives of Pediatrics & Adolescent Medicine·Debra A MurphyUNKNOWN Adolescent Medicine HIV/AIDS Research Network
Sep 28, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Stephen F MorinMargaret A Chesney
May 24, 2006·Archives of Internal Medicine·Robert L SpitzerBernd Löwe
Jun 19, 2007·Journal of Substance Abuse Treatment·Carlo C DiClementeAlan S Bellack
Feb 1, 2008·American Journal of Public Health·Deborah LevineJeffrey D Klausner
Feb 21, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jason A CrawKarla Schmitt
Mar 19, 2008·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Jennifer L Brown, Peter A Vanable
Aug 9, 2008·Lancet·Michael H MersonChantawipa Apisuk
Oct 3, 2008·AIDS and Behavior·Mary Jane Rotheram-BorusBarbara Ingram
Dec 19, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Deborah CohanJeffrey D Klausner
Nov 17, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jane M SimoniThomas M Hooton
Dec 10, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marguerita LightfootNaihua Duan
Jan 21, 2010·Current Opinion in Psychiatry·Dallas Swendeman, Mary Jane Rotheram-Borus
Mar 24, 2010·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·W Scott ComuladaMargaret A Chesney
May 28, 2010·Family Practice·Renée I Boothroyd, Edwin B Fisher
Oct 14, 2010·Current HIV/AIDS Reports·Ann E KurthJudith N Wasserheit
Mar 4, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Edward M GardnerWilliam J Burman
Jun 28, 2011·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·Linda J Koenig, Donna Hubbard McCree
Jul 19, 2011·Translational Behavioral Medicine·Mary Jane Rotheram-BorusMyralyn Nartey
Aug 23, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jeffrey S GonzalezSteven A Safren
Jan 11, 2012·Health Affairs·Edwin B FisherChanuantong Tanasugarn
Mar 8, 2012·The Journal of Behavioral Health Services & Research·Melissa KimberGwendolyn Fearing
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Tara HorvathGeorge W Rutherford
Apr 28, 2012·Lancet·Russell M VinerCandace Currie
May 2, 2012·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Megan A LewisLisa M Kuhns
Aug 28, 2012·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Sulachni ChandwaniLawrence D'Angelo

❮ Previous
Next ❯

Citations

Mar 23, 2019·JMIR Research Protocols·Chelsea Lee ShannonUNKNOWN Adolescent Medicine Trials Network CARES Team
Aug 15, 2020·Current HIV/AIDS Reports·Keshet RonenBrandon L Guthrie
Aug 11, 2019·JMIR Research Protocols·Dallas SwendemanUNKNOWN Adolescent Medicine Trials Network (ATN) CARES Team
Jan 22, 2019·JMIR Research Protocols·Mary Jane RotheramUNKNOWN Adolescent Medicine Trials Network (ATN) CARES Team
May 9, 2021·BMC Infectious Diseases·Talitha Crowley, Anke Rohwer
Jan 22, 2022·Public Health Reports·Hilary GoldhammerAlex S Keuroghlian

❮ Previous
Next ❯

Methods Mentioned

BETA
blood draw
Assay

Clinical Trials Mentioned

NCT03109431

Software Mentioned

AMMI
Power Analysis and Sample Size
CommCare

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.