The stereospecificity of hydrogen transfer to NAD(P)+ catalyzed by lactol dehydrogenases

Biochemical and Biophysical Research Communications
S B MostadA Glasfeld

Abstract

The stereochemistry of hydrogen transfer to NAD(P)+ has been determined for five lactol dehydrogenases. It was found that D-glucose dehydrogenases from Bacillus megaterium and Cryptococcus uniguttulatus and L-rhamnose dehydrogenase from Aureobasidium pullulans are pro-S (B) specific, while D-glucose dehydrogenase from Thermoplasma acidophilum and D-xylose dehydrogenase from procine liver are pro-R (A) specific. The latter two enzymes are the first examples of A-specific dehydrogenases oxidizing aldoses at the anomeric carbon. These findings are discussed in terms of functional and historical models that seek to make predictive generalizations regarding dehydrogenase stereospecificity.

References

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Nov 15, 1977·Biochemistry·R M GaravitoW Eventoff
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Mar 1, 1994·The Plant Journal : for Cell and Molecular Biology·K GraeveR Scheibe

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Citations

May 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tobias J ErbBirgit E Alber
Aug 2, 2008·The FEBS Journal·Werner Römisch-MarglMarkus Fischer
Dec 5, 2003·Analytical Biochemistry·Jocelyn A McCrackenAmnon Kohen
Jan 21, 2015·Chembiochem : a European Journal of Chemical Biology·Ryohei TakeishiTadashi Eguchi
May 20, 2005·Extremophiles : Life Under Extreme Conditions·Yasuhiro ShimizuToshihisa Ohshima
Oct 26, 2018·PloS One·Nichole F Huntley, John F Patience

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