PMID: 1200995Sep 1, 1975Paper

The stereospecificity of sequential nicotinamide-adenine dinucleotide-dependent oxidoreductases in relation to the evolution of metabolic sequences

The Biochemical Journal
K H do Nascimento, D D Davies

Abstract

The generalization that 'when a metabolic sequence involves consecutive nicotinamide-adenine dinucleotide-dependent reactions, the dehydrogenases have the same stereospecificity' was tested and confirmed for three metabolic sequences. (1) NAD+-xylitol (D-xylulose) dehydrogenase and NADP+-xylitol (L-xylulose) dehydrogenase are both B-specific. (2) D-Mannitol 1-phosphate dehydrogenase and D-sorbitol 6-phosphate dehydrogenase are both B-specific. (3) meso Tartrate dehydrogenase and oxaloglycollate reductive decarboxylase are both A-specific. Other dehydrogenases associated with the metabolism of meso-tartrate in Pseudomonas putida, such as hydroxypyruvate reductase and tartronate semialdehyde reductase, were also shown to be A-specific. Malate dehydrogenase from Pseudomonas putida was A-specific, and the proposition is discussed that the common A-stereospecificity among the dehydrogenases involved in meso-tartrate metabolism reflects their origin from malate dehydrogenase.

Citations

Aug 1, 1976·FEBS Letters·M A AlizadeK Gaede
Aug 7, 2003·Applied and Environmental Microbiology·Jung-Kul LeeHyung-Hwan Hyun
Sep 19, 2012·Applied Microbiology and Biotechnology·Paul SchweigerUwe Deppenmeier
Jan 1, 1983·The International Journal of Biochemistry·S S Wong, L J Wong
Oct 15, 1981·Archives of Biochemistry and Biophysics·R C Kiser, W G Niehaus

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