The Steroid Profile of Adrenal Incidentalomas: Subtyping Subjects With High Cardiovascular Risk

The Journal of Clinical Endocrinology and Metabolism
Guido Di DalmaziUberto Pagotto

Abstract

Steroid profiling by mass spectrometry has shown implications for diagnosis and subtyping of adrenal tumors. To investigate steroid profiles and their cardiovascular correlates in a large cohort of patients with nonsecreting (NS) adrenal incidentalomas and autonomous cortisol secretion (ACS). Cohort study. University hospital. Patients (n = 302) with incidentally discovered adrenal masses, divided into unilateral adenoma and hyperplasia with ACS (n = 46 and n = 52, respectively) and NS (n = 120 and n = 84, respectively). Post-dexamethasone suppression test (DST) cortisol <50 or >50 nmol/L defined NS and ACS, respectively. Analysis of 10-steroid panel by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and clinical data (mean follow-up 39 months). Difference in baseline and post-DST steroid profiles between groups. Correlation with cardiovascular profile. Patients with unilateral adenomas and ACS showed higher cortisol, 11-deoxycortisol, and corticosterone and lower dehydroepiandrosterone than those with NS adenomas. Patients with ACS hyperplasia showed higher cortisol and lower androgens in women than those with NS. Patients with ACS had reduced suppression of post-DST cortisol, 11-deoxycortisol, and corticosterone, ir...Continue Reading

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Citations

Sep 3, 2020·The Journal of Clinical Endocrinology and Metabolism·Guido Di DalmaziCristina L Ronchi
Dec 6, 2020·Annales d'endocrinologie·Sophie CambosAntoine Tabarin
Apr 6, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Carmen ArestaIacopo Chiodini
May 26, 2020·Best Practice & Research. Clinical Endocrinology & Metabolism·Sophie Cambos, Antoine Tabarin
Sep 2, 2020·Cancer Treatment and Research Communications·Ahmed YousafJoanna Kolodney
Jun 6, 2021·The Journal of Steroid Biochemistry and Molecular Biology·James P TeuberJuilee Rege
Jun 24, 2021·Journal of Endocrinological Investigation·F CeccatoM Boscaro
Mar 20, 2021·The Journal of Clinical Endocrinology and Metabolism·Jonathan Wolf MuellerMatthias Kroiss
Aug 14, 2020·Current Pharmaceutical Design·Miomira IvovićSvetlana Vujović
Oct 17, 2021·Scientific Reports·Marta Araujo-CastroPablo Valderrábano
Oct 29, 2021·Der Internist·Anna Riester, Felix Beuschlein
Oct 23, 2021·Endocrinology and Metabolism·Eu Jeong KuMan Ho Choi
Oct 20, 2021·The Journal of Clinical Endocrinology and Metabolism·Kristina BerkeGraeme Eisenhofer

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