PMID: 8958791Nov 1, 1996Paper

The steroidogenic effects of beta-endorphin and joining peptide: a potential role in the modulation of adrenal androgen production

The Journal of Endocrinology
D ClarkeT J McKenna

Abstract

This study examines the androgen-stimulating properties of pro-opiomelanocortin-derived peptides, ACTH, beta-endorphin (beta-End) and joining peptide (JP). Ten different cell suspensions were prepared from ten human adrenal glands. ACTH and JP stimulated cortisol, androstenedione (delta 4) and dehydroepiandrosterone (DHEA) production (P < 0.05); beta-End stimulated only delta 4 and DHEA production. beta-End brought about significant increases in the delta 4 or DHEA to cortisol ratios. The addition of beta-End (10(-10) M) suppressed ACTH-stimulated cortisol production from 7573 +/- 2960 to 5994 +/- 2654 pmol/10(6) cells (means +/- S.E.M.; P < 0.05). The addition of beta-End did not affect ACTH-stimulated delta 4 production (210 +/- 88 and 236 +/- 105 pmol/10(6) cells). JP (10(-10) M) inhibited ACTH-stimulated cortisol production so that the mean values fell to 5186 +/- 2588 and also inhibited DHEA production, from 240 +/- 48 to 180 +/- 33 pmol/10(6) cells. These results suggest that the relative production of androgen to cortisol is greater in response to beta-End and JP than in response to ACTH. If blood levels of these peptides rise to herald adrenarche as reported for beta-End, suppression of cortisol production may result in...Continue Reading

Citations

Jun 1, 1997·Baillière's Clinical Obstetrics and Gynaecology·T J McKennaS K Cunningham
Nov 9, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·S H van GoozenH van Engeland
Aug 8, 2006·Acta Psychiatrica Scandinavica·R YehudaR-K Yang
Apr 3, 2001·European Journal of Clinical Investigation·D l'Allemand, A Biason-Lauber
Jul 6, 2018·European Journal of Endocrinology·Athanasios FountasNiki Karavitaki
Nov 24, 1999·The Journal of Clinical Endocrinology and Metabolism·T Remer, F Manz
Oct 10, 2018·European Journal of Endocrinology·Athanasios FountasNiki Karavitaki
Mar 8, 2021·Molecular and Cellular Endocrinology·Typhanie Dumontet, Antoine Martinez

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