PMID: 39738Jan 1, 1979

The stimulant effect of neuroleptics: myth or reality?

L Colonna, M Petit


On the basis of clinical observations and animal pharmacology, the hypothesis of two types of neuroleptics may be considered. Some neuroleptics ("monopolars") are always sedatives, whatever will be the dosage used practically. Other neuroleptics ("bipolars") would be stimulating at a low dosage and sedatives at a high dosage. Stimulation and sedation would be in relation with pre- and post-synaptic dopaminergic receptors blockade.

Related Concepts

Antipsychotic Effect
Central Nervous System Stimulant [EPC]
Central Nervous System Stimulants
Antipsychotic Agents
Dopamine Receptor
Dose-Response Relationship, Drug

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