PMID: 39738Jan 1, 1979

The stimulant effect of neuroleptics: myth or reality?

L'Encéphale
L Colonna, M Petit

Abstract

On the basis of clinical observations and animal pharmacology, the hypothesis of two types of neuroleptics may be considered. Some neuroleptics ("monopolars") are always sedatives, whatever will be the dosage used practically. Other neuroleptics ("bipolars") would be stimulating at a low dosage and sedatives at a high dosage. Stimulation and sedation would be in relation with pre- and post-synaptic dopaminergic receptors blockade.

Related Concepts

Antipsychotic Effect
Central Nervous System Stimulant [EPC]
Central Nervous System Stimulants
Antipsychotic Agents
Sedatives
Stimulant
Dopamine Receptor
Blockade
Analeptics
Dose-Response Relationship, Drug

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