PMID: 2484408Dec 1, 1989Paper

The stimulation of metallothionein synthesis in neuroblastoma IMR-32 by zinc and cadmium but not dexamethasone

Biological Trace Element Research
M EbadiP Timmins

Abstract

Metallothioneins are a class of cysteine-rich and low molecular weight, metal-binding proteins that are inducible by a wide variety of agents, including metal ions, such as cadmium and zinc, glucocorticoid hormones, interferon, and tumor promoters. In an effort to delineate the regulation of the synthesis of the recently identified brain metallothionein-like protein, a study was undertaken to compare the induction of metallothionein in human neuroblastoma IMR-32 cells by zinc, cadmium, and dexamethasone using the human Chang liver cells as a control. Both cadmium (1 microM) and zinc (100 microM) significantly enhanced the incorporation of [35S]cysteine into metallothioneins isolated from both neuroblastoma and Chang liver cells. Dexamethasone in concentrations of 10 microM stimulated the synthesis of metallothionein in the Chang cells, whereas it had no effects on the synthesis of metallothionein in the neuroblastoma cells at concentrations ranging from 2.5--100 microM. The degree of stimulation of metallothionein synthesis in the Chang cells by cadmium and zinc was significantly higher than seen in neuroblastoma cells. The neuroblastoma IMR-32 exhibited less tolerance to the toxicity of both cadmium and zinc than the Chang cel...Continue Reading

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Citations

Jul 1, 1995·Neurochemistry International·M EbadiR F Pfeiffer
Aug 1, 1996·Neurochemistry International·M EbadiP Rojas
Nov 1, 1994·General Pharmacology·M Ebadi, P L Iversen
Jul 1, 1996·Critical Reviews in Food Science and Nutrition·M S Tapia de DazaJ W Chanes

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