PMID: 37138May 1, 1979

The stimulus-secretion coupling of glucose-induced insulin release. XXXV. The links between metabolic and cationic events

W J MalaisseAbdullah Sener


When isolated rat islets were exposed to glucose, the concentrations of NADH and NADPH, and the NADH/NAD+ and NADPH/NADP+ ratios were increased. The dose-response curve resembled that characterising the glucose-induced secondary rise in 45Ca efflux, displaying a sigmoidal pattern with a half-maximal value at glucose 7.5 mmol/l. The glucose-induced increase in NAD(P)H was detectable within 1 min of exposure to the sugar. Except for the fall in ATP concentration and ATP/ADP ratio found at very low glucose concentrations (zero to 1.7 mmol/l) no effect of glucose (2.8-27.8 mmol/l) upon the steady-state concentration of adenine nucleotides was observed. However, a stepwise increase in glucose concentration provoked a dramatic and transient fall in the ATP concentration, followed by a sustained increase in both O2 consumption and oxidation of exogenous + endogenous nutrients. This may be essential to meet the energy requirements in the stimulated B-cell. Although no significant effect of glucose upon intracellular pH was detected by the 5,5-dimethyloxazolidine-2,4-dione method, the net release of H+ was markedly increased by glucose, with a hyperbolic dose-response curve (half-maximal response at glucose 2.9 mmol/l) similar to that c...Continue Reading


Apr 1, 1979·Metabolism: Clinical and Experimental·W J MalaisseJ C Hutton
Mar 1, 1975·Endocrinology·J W LeitnerF H Schneider
Jan 1, 1977·Biochemical Society Transactions·W J Malaisse
Mar 20, 1978·Pflügers Archiv : European journal of physiology·W J MalaisseJ C Hutton
Jul 18, 1978·Pflügers Archiv : European journal of physiology·S KawazuW J Malaisse
Apr 28, 1978·Annals of the New York Academy of Sciences·W J MalaisseE Rojas
Apr 15, 1979·Archives of Biochemistry and Biophysics·W J MalaisseAbdullah Sener
Sep 1, 1976·The American Journal of Physiology·J C Henquin, A E Lambert
Jan 1, 1976·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H P Meissner, I Atwater
Sep 1, 1977·Diabetologia·G DevisW J Malaisse
Feb 1, 1973·The Biochemical Journal·S J AshcroftP J Randle
May 1, 1972·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K Asplund, C Hellerström
Jan 1, 1972·Endocrinology·B HellmanI B Täljedal
May 1, 1973·The Journal of Clinical Investigation·E Van ObberghenW J Malaisse
Apr 1, 1969·Physiological Reviews·W J Waddell, R G Bates
Jun 1, 1973·The Biochemical Journal·D J Deery, K W Taylor


Oct 29, 2002·International Journal of Cancer. Journal International Du Cancer·M MurataShosuke Kawanishi
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·Yusuke HirakuShosuke Kawanishi
May 1, 1987·Diabetologia·Daniel Pipeleers
Jul 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·S KawazuW J Malaisse
Aug 1, 1987·Pflügers Archiv : European journal of physiology·N C SturgessM L Ashford
Aug 1, 1981·Pflügers Archiv : European journal of physiology·W J MalaisseAbdullah Sener
Nov 1, 1986·Pflügers Archiv : European journal of physiology·G TrubeT Ohno-Shosaku
Dec 1, 1980·Pflügers Archiv : European journal of physiology·G SomersW J Malaisse
Oct 15, 1984·Experientia·Abdullah Sener, W J Malaisse
Oct 15, 1984·Experientia·W J MalaisseAbdullah Sener
Aug 15, 1983·Experientia·R DrouhaultB Dufy
Jul 1, 1981·Molecular and Cellular Biochemistry·W J MalaisseF Malaisse-Lagae
Mar 1, 2005·Environmental Health and Preventive Medicine·S Oikawa
Feb 3, 2009·Cell Biochemistry and Biophysics·Nathan R Perron, Julia L Brumaghim
Aug 7, 1992·Biochimica Et Biophysica Acta·M ErecińskaD Nelson
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Apr 28, 1980·Life Sciences·W J MalaisseAbdullah Sener
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Feb 1, 1981·Molecular and Cellular Endocrinology·J C Henquin
Oct 1, 1983·Molecular and Cellular Endocrinology·L Best, W J Malaisse
Feb 1, 1987·Molecular and Cellular Endocrinology·M H GiroixW J Malaisse
Apr 17, 1990·Molecular and Cellular Endocrinology·W S Zawalich, H Rasmussen
Apr 19, 1996·Molecular and Cellular Endocrinology·D Mercan, W J Malaisse
Jan 1, 1990·Cellular Signalling·S J Ashcroft, F M Ashcroft
Oct 6, 1999·Molecular and Cellular Endocrinology·A P SalgadoR Ramasamy
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Feb 26, 2014·BMC Medical Genomics·Yang PuYang Cao
Oct 1, 1980·Journal of Endocrinological Investigation·A R Carpinelli, W J Malaisse
Oct 1, 2013·Journal of Theoretical Biology·Erica J Graham, Frederick R Adler
Feb 13, 2001·Biochemical and Biophysical Research Communications·S OhnishiShosuke Kawanishi
Nov 24, 1999·Archives of Biochemistry and Biophysics·Y OhkumaShosuke Kawanishi
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Sep 1, 1979·FEBS Letters·Abdullah SenerW J Malaisse
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Sep 10, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K LouchamiW J Malaisse
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Feb 15, 2001·Japanese Journal of Cancer Research : Gann·S OhnishiShosuke Kawanishi
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