The stimulus-secretion coupling of glucose-induced insulin release: fuel metabolism in islets deprived of exogenous nutrient

Archives of Biochemistry and Biophysics
W J MalaisseA Sener

Abstract

The fuel hypothesis for insulin release postulates that the secretory response to nutrient secretagogues reflects their capacity to augment catabolic fluxes in pancreatic islet cells. Hence, both the oxidation of exogenous nutrients and their effect upon the metabolism of endogenous nutrients should be taken into consideration to account for the stimulation of insulin release. In the present work, an attempt was made to quantify the respective contribution of carbohydrates, fatty acids, and amino acids in the respiration of islets deprived of exogenous nutrient. The metabolism of glycerol, fatty acids, and amino acids was found to account for the major part of the basal respiratory rate. Glucose modestly decreased the oxidation of endogenous fatty acids, lowered the production of NH4+, but did not impair the oxidative catabolism of 2-keto acids derived from endogenous amino acids. These findings suggest that the catabolism of noncarbohydrate nutrients largely contributes to the respiration of the islets, even when the latter are exposed to circulating glucose in its physiological concentration.

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Citations

Jan 12, 1995·Molecular and Cellular Biochemistry·R RamirezW J Malaisse
Oct 15, 1984·Experientia·A Sener, W J Malaisse
Aug 7, 1992·Biochimica Et Biophysica Acta·M ErecińskaD Nelson
Jan 1, 1986·Advances in Enzyme Regulation·W J Malaisse
Aug 1, 1987·Molecular and Cellular Endocrinology·M T YilmazW J Malaisse
Jan 30, 2002·Progress in Lipid Research·Simon Eaton
May 21, 2010·American Journal of Physiology. Endocrinology and Metabolism·D M FaleckY Imai
Jan 7, 2005·Nutrition & Metabolism·Zahra Fatehi-Hassanabad, Catherine B Chan
Jun 19, 2008·Journal of Cell Science·Daniel A CunhaMiriam Cnop
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Danhong LuA Dean Sherry
Jan 1, 1986·Diabetes/metabolism Reviews·M D Meglasson, F M Matschinsky
Jan 30, 2002·Diabetes·Robert T KennedySung-Kwon Jung
Mar 23, 2018·Nutrients·Paloma Acosta-Montaño, Víctor García-González
Mar 10, 2017·Physiological Reviews·T D MüllerM H Tschöp
Feb 28, 2001·Diabetes, Obesity & Metabolism·C M Amery, M Nattrass
Dec 14, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·F Assimacopoulos-Jeannet
Sep 2, 2016·Physiological Reviews·David G Nicholls
Jan 13, 2004·Physiological Reviews·Mark J DunneKeith J Lindley
Mar 18, 2000·The Journal of Nutrition·B E CorkeyM Prentki
Feb 3, 2019·Journal of Cellular and Molecular Medicine·Jeff JiDusica Maysinger
Apr 8, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bo He, Régis Moreau
Jul 1, 1990·The American Journal of Physiology·W J MalaisseA Sener
Sep 1, 2000·Seminars in Cell & Developmental Biology·J T DeeneyB E Corkey
Aug 1, 1992·Metabolism: Clinical and Experimental·W J MalaisseA Sener
Jan 1, 1992·Archives of Biochemistry and Biophysics·W J Malaisse, A Sener
Oct 30, 1985·Biochemical and Biophysical Research Communications·M E Dunlop, R G Larkins

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