PMID: 3929768Jul 1, 1985

The stoichiometry of the exchange catalysed by the mitochondrial calcium/sodium antiporter

The Biochemical Journal
M D Brand

Abstract

Rat heart mitochondria respiring on succinate in the presence of Ruthenium Red (to inhibit uptake on the Ca2+ uniporter) released Ca2+ on the calcium/sodium antiporter until a steady state was reached. Addition of the ionophore A23187 (which catalyses Ca2+/2H+ exchange) did not perturb this steady state. Thermodynamic analysis showed that if a Ca2+/nNa+ exchange with any value of n other than 2 was at equilibrium, addition of A23187 would cause an obvious change in extramitochondrial free [Ca2+]. Therefore the endogenous calcium/sodium antiporter of mitochondria catalyses electroneutral Ca2+/2Na+ exchange.

Citations

Oct 1, 1994·Journal of Bioenergetics and Biomembranes·K K Gunter, T E Gunter
Jul 3, 1999·Physiological Reviews·M P Blaustein, W J Lederer
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Jul 24, 2012·The Journal of Biological Chemistry·Raz PaltyIsrael Sekler
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Onium Compounds

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