PMID: 2492943Feb 1, 1989Paper

The Stonehouse study: secretor status and carriage of Neisseria species

Epidemiology and Infection
C Caroline BlackwellD M Jones

Abstract

The genetically determined inability to secrete the water-soluble glycoprotein form of the ABO blood group antigens into saliva and other body fluids is a recognized risk factor for meningococcal disease. During a community-wide investigation of a prolonged outbreak of disease due to a B15:P1.16 sulphonamide-resistant strain of Neisseria meningitidis in Stonehouse, Gloucestershire (the Stonehouse survey), the ABO blood group and secretor status of almost 5000 residents was determined. The proportion of non-secretors in the Stonehouse population was significantly higher than the proportion of non-secretors among blood donors in the South West Region and in England generally. Seven of 13 Stonehouse residents with meningococcal disease who were tested were found to be non-secretors, a high proportion. The outbreak in Stonehouse cannot be explained solely in terms of the increased proportion of non-secretors. There was no clear correlation between the proportions of non-secretors in different areas within the town and the incidence of cases of meningococcal disease. Carriers of meningococci, whether outbreak or other strains, were not more likely to be non-secretors. The reasons why non-secretors are more susceptible to meningococc...Continue Reading

Citations

Jun 1, 1992·Epidemiology and Infection·C C BlackwellN Fatouros
Apr 1, 1990·Epidemiology and Infection·C C BlackwellR J Fallon
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W D HamiltonR Tanese
Oct 5, 1991·BMJ : British Medical Journal·M W RazaD M Weir
Jun 1, 1994·Gut·W DickeyJ C McLoughlin
Oct 10, 2014·National Journal of Maxillofacial Surgery·Akhilanand Chaurasia
Aug 1, 1990·Journal of Clinical Periodontology·J A Sofaer
Oct 17, 1998·Australian Dental Journal·G C TownsendP M Bartold
Sep 13, 2011·Expert Review of Anti-infective Therapy·Montse Soriano-GabarróAndrew Vyse
Apr 14, 1999·Periodontology 2000·M J Aldred, P M Bartold
Oct 1, 1996·Scandinavian Journal of Gastroenterology·M A HeneghanC F McCarthy

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