The Streptococcus pyogenes capsule is required for adhesion of bacteria to virus-infected alveolar epithelial cells and lethal bacterial-viral superinfection

Infection and Immunity
Shigefumi OkamotoShigeyuki Hamada

Abstract

An apparent worldwide resurgence of invasive group A Streptococcus (GAS) infections remains unexplained. However, we recently demonstrated in mice that when an otherwise nonlethal intranasal GAS infection is preceded by a nonlethal influenza A virus (IAV) infection, induction of lethal invasive GAS infections is often the result. In the present study, we established several isogenic mutants from a GAS isolate and evaluated several virulence factors as candidates responsible for the induction of invasive GAS infections. Disruption of the synthesis of the capsule, Mga, streptolysin O, streptolysin S, or streptococcal pyrogenic exotoxin B of GAS significantly reduced mortality among mice superinfected with IAV and a mutant. In addition, the number of GAS organisms adhering to IAV-infected alveolar epithelial cells was markedly reduced with the capsule-depleted mutant, although this was not the case with the other mutants. Wild-type GAS was found to bind directly to IAV particles, whereas the nonencapsulated mutant showed much less ability to bind. These results suggest that the capsule plays a key role in the invasion of host tissues by GAS following superinfection with IAV and GAS.

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Citations

May 23, 2007·Pediatric Research·Bart E Van EwijkCornelis K Van der Ent
May 7, 2013·Future Microbiology·Sabri BousbiaBernard La Scola
Feb 8, 2008·Experimental Animals·Atsushi YonedaYasunobu Matsumoto
Apr 6, 2016·Frontiers in Microbiology·Andrea L HerreraMichael S Chaussee
Jun 2, 2015·Scientific Reports·Cheryl-lynn Y OngAlastair G McEwan
Sep 23, 2014·The European Respiratory Journal·Brian G G OliverJudy Black
Dec 28, 2007·The Journal of Biological Chemistry·Yutaka TeraoShigetada Kawabata
Nov 21, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fahad GulraizFrank R Stassen
Apr 17, 2013·The Journal of Biological Chemistry·Mariko Honda-OgawaShigetada Kawabata

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