PMID: 9535147Apr 16, 1998Paper

The stress hormone adrenocorticotropin enhances sympathetic outflow to the muscle vascular bed in humans

Journal of Hypertension
C DodtM Elam

Abstract

To examine the role of adrenocorticotropin in the regulation of the sympathetic outflow to the muscle vascular bed in healthy female humans. Eight healthy, nonsmoking female subjects (aged 18-33 years) were examined before and after injection of 0.25 mg adrenocorticotropin 1-24 or placebo according to a balanced, double-blind cross-over protocol. Muscle sympathetic nerve activity, arterial pressure, and heart rate were continuously recorded both under basal conditions and during a 50 min period after injection of each substance. Furthermore, sympathoexcitatory capacities of inspiratory apneas and cold pressure tests performed before and after injection of adrenocorticotropin were determined. The injection of adrenocorticotropin rapidly increased burst frequency of muscle sympathetic nerve activity (P < 0.01). The maximal effect of adrenocorticotropin, with an increase in burst frequency of 63%, occurred during the third minute after injection and waned subsequently, but muscle sympathetic nerve activity remained significantly increased during the first 10 min after injection. The stimulatory effect of adrenocorticotropin had disappeared 40 min after injection. The sympathoexcitatory capacity of a maximal inspiratory apnea and a...Continue Reading

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Citations

May 7, 2004·Current Hypertension Reports·Kevin P Davy
Jul 16, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Philippe ChessexJean-Claude Lavoie
Nov 21, 2012·Metabolism: Clinical and Experimental·Daniël H van RaalteMichaela Diamant
Jul 8, 2008·Neuroscience and Biobehavioral Reviews·Kevin P Davy, Jeb S Orr
Sep 13, 2005·Metabolism: Clinical and Experimental·Christian BenedictWerner Kern
May 4, 2017·Journal of Neurogastroenterology and Motility·Cristina StasiRosa Maria Bruno
Aug 18, 2009·Journal of Hypertension·Andréia Zavaloni ScalcoFrancisco Lotufo-Neto
Mar 22, 2008·Pediatric Research·Michal J StarkIan M R Wright
Apr 26, 2003·Journal of Hypertension·Gunther WeitzChristoph Dodt
Jun 14, 2000·The Journal of Clinical Endocrinology and Metabolism·G K Adler
Jun 24, 2015·Journal of Hypertension·Vasilios KotsisUNKNOWN WG on Obesity, Diabetes, the High Risk Patient, European Society of Hypertension

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