The stress reaction and its molecular events: splicing variants

Biochemical and Biophysical Research Communications
Li-Ling TangCai-Xin Sun

Abstract

The growth of cells and tissues is regulated by stress. When body is injured, it manifests a large spectrum of metabolic, endocrine, and immune alterations, which is named stress reaction. Among them, the production of growth factors may play a critical role. For osteoblasts and myoblasts, IGF-I has been shown to be involved in the process of cells in response to overloads. There are two splicing forms, one is IGF-Ea, the other is the IGF-IEb in the rodents and corresponds to IGF-IEc in humans. The latter is markedly up-regulated in response to overloads. Therefore, it has been named mechanogrowth factor. The link between the mechanical stimulus and the gene expression represents a new and important area in cell science. Understanding the process of splicing in IGF-I helps one to investigate the mechanotransduction of cells in response to mechanical stimulation at molecular level.

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Citations

May 10, 2007·Biomechanics and Modeling in Mechanobiology·G P RaeberJ A Hubbell
May 25, 2010·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Zhongquan DaiYinghui Li
Feb 14, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·David Karasik, Douglas P Kiel
Aug 17, 2019·Biomaterials·Jason WangNenad Bursac

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