PMID: 6164348Mar 1, 1981Paper

The stringent response to unacylated tRNA, energy-and temperature-downshift in Bacillus stearothermophilus

Archives of Microbiology
S Fehr, D Richter

Abstract

The response of the thermophile Bacillus stearothermophilus to inhibition of tRNA acylation, energy starvation and temperature downshift was characterized. We found that B. stearothermophilus, like other prokaryotic organisms, reacts with the so-called stringent response, which includes the accumulation of the unusual nucleotides guanosine 3',5' bis (diphosphate) [ppGpp] and guanosine 3'-diphosphate, 5'-tri-phosphate [pppGpp] and concomitantly the reduction of RNA synthesis and growth rate. The amount of (p)ppGpp formed depended on the cause of the stringent response: when tRNA acylation was inhibited (p)ppGpp synthesis was much higher than after energy starvation or temperature downshift whereas RNA synthesis was totally blocked in each case.

References

Jan 1, 1979·Annual Review of Genetics·J A Gallant
Feb 15, 1977·Molecular & General Genetics : MGG·C KariA Travers
Apr 1, 1978·Canadian Journal of Biochemistry·G Chaloner-Larsson, H Yamazaki
Jun 1, 1978·Canadian Journal of Biochemistry·W A Bridger, W Paranchych
Mar 1, 1979·Microbiological Reviews·R H Silverman, A G Atherly
Aug 2, 1976·Biochimica Et Biophysica Acta·W J WeyerM Gruber
Nov 1, 1976·Canadian Journal of Biochemistry·G Chaloner-Larsson, H Yamazaki
Dec 1, 1975·The Biochemical Journal·A OgilvieW Kersten
Oct 1, 1975·Journal of Bacteriology·J J RoweR E Amelunxen
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H L YangM Cashel
Aug 5, 1974·Biochemical and Biophysical Research Communications·E HölttäJ Pispa
Feb 15, 1972·Biochemistry·R B Harshman, H Yamazaki
Jul 10, 1974·Biochemical and Biophysical Research Communications·S R Khan, H Yamazaki
Oct 10, 1968·Biochemical and Biophysical Research Communications·Y SokawaY Kaziro
Mar 14, 1967·Journal of Molecular Biology·G Edlin, J Neuhard
Mar 25, 1963·Biochemical and Biophysical Research Communications·D P KESSLER, H V RICKENBERG

❮ Previous
Next ❯

Citations

Jan 1, 1983·Zeitschrift für allgemeine Mikrobiologie·K Riedel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.