The structural and functional heterogeneity of glutamic acid decarboxylase: a review

Neurochemical Research
M G Erlander, A J Tobin

Abstract

Studies of the GABA-synthetic enzyme glutamate decarboxylase (glutamic acid decarboxylase; GAD; E.C.4.1.1.15) began in 1951 with the work of Roberts and his colleagues. Since then, many investigators have demonstrated the structural and functional heterogeneity of brain GAD. At least part of this heterogeneity derives from the existence of two GAD genes.

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Related Concepts

Brain Diseases
GAD1
Neurons
Brain
Glutamate Decarboxylase
Gammalon
Gamma-Aminobutyric Acid, Zinc Salt (2:1)
Metazoa

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