The structural basis of interlamellar cohesion in the intervertebral disc wall

Journal of Anatomy
Celina A PezowiczNeil D Broom

Abstract

The purpose of this study was to investigate the structural mechanisms that create cohesion between the concentric lamellae comprising the disc annulus. Sections, 50-60 microm thick, were obtained using a carefully chosen cutting plane that incorporated the fibrous component in alternating lamellae as in-plane and cross-sectioned arrays. These sections were then subjected to microtensile stretching both across (radial) and along (tangential) the in-plane fibre direction, in their fully hydrated state. Structural responses were studied by simultaneously viewing the sections using high-resolution Nomarski interference contrast light microscopy. Additional bulk samples of annulus were fixed while held in a constant, radially stretched state in order to investigate the potential for interlamellar separation to occur in a state more representative of the intact disc wall. The study has provided a detailed picture of the structural architecture creating disc wall cohesion, revealing a complex hierarchy of interconnecting relationships within the disc wall, not previously described. Importantly, because our experimental approach offers a high-resolution view of the response of the interlamellar junction to deformation in its fully hyd...Continue Reading

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Citations

Nov 1, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·James MelroseChristopher B Little
Nov 14, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Rita KandelJill P G Urban
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