The structural basis of semantic control: Evidence from individual differences in cortical thickness

NeuroImage
Xiuyi WangElizabeth Jefferies

Abstract

Semantic control allows us to shape our conceptual retrieval to suit the circumstances in a flexible way. Tasks requiring semantic control activate a large-scale network including left inferior prefrontal gyrus (IFG) and posterior middle temporal gyrus (pMTG) - this network responds when retrieval is focussed on weak as opposed to dominant associations. However, little is known about the biological basis of individual differences in this cognitive capacity: regions that are commonly activated in task-based fMRI may not relate to variation in controlled retrieval. The current study combined analyses of MRI-based cortical thickness with resting-state fMRI connectivity to identify structural markers of individual differences in semantic control. We found that participants who performed relatively well on tests of controlled semantic retrieval showed increased structural covariance between left pMTG and left anterior middle frontal gyrus (aMFG). This pattern of structural covariance was specific to semantic control and did not predict performance when harder non-semantic judgements were contrasted with easier semantic judgements. The intrinsic functional connectivity of these two regions forming a structural covariance network over...Continue Reading

References

Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·S L Thompson-SchillM J Farah
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·S L Thompson-SchillR T Knight
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Sep 28, 2000·Trends in Neurosciences·J Duncan, A M Owen
Apr 27, 2002·Journal of Neurophysiology·M F S RushworthP K Sipila
Jul 1, 1964·Journal of Abnormal Psychology·M T MEDNICKE V MEDNICK
May 1, 1962·Psychological Review·S A MEDNICK
Jun 5, 2004·Neuropsychologia·U NoppeneyC Price
Jan 7, 2005·Cerebral Cortex·Jennifer M RoddIngrid S Johnsrude
Apr 6, 2005·NeuroImage·Thomas NicholsJean-Baptiste Poline
Aug 27, 2005·Human Brain Mapping·E LudersA W Toga
Oct 11, 2005·Trends in Cognitive Sciences·Mark Jung-Beeman
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brian T GoldAnders H Andersen
Jul 4, 2006·Brain : a Journal of Neurology·Elizabeth Jefferies, Matthew A Lambon Ralph
Jan 12, 2007·Journal of Cognitive Neuroscience·Hakwan C LauRichard E Passingham
Aug 7, 2007·Neuropsychologia·David Badre, Anthony D Wagner
Aug 25, 2007·Behavioral and Cognitive Neuroscience Reviews·David Badre, Anthony D Wagner
Nov 21, 2007·Nature Reviews. Neuroscience·Karalyn PattersonTimothy T Rogers
Oct 10, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yu Yong ChoiKun Ho Lee
Oct 15, 2008·NeuroImage·Chiao-Yun ChenChi-Hung Juan
Apr 21, 2009·Neuron·William W SeeleyMichael D Greicius
May 29, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rogier B MarsMatthew F S Rushworth
Feb 1, 2008·Aphasiology·Connie A TompkinsWiltrud Fassbinder
Jul 16, 2010·Brain and Language·Erin Nicole Moore-ParksRalph-Axel Müller
Nov 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul HoffmanMatthew A Lambon Ralph
Mar 17, 2011·Nature Reviews. Neuroscience·Ryota Kanai, Geraint Rees
Jun 10, 2011·Journal of Neurophysiology·B T Thomas YeoRandy L Buckner
Aug 11, 2011·NeuroImage·Christina SchillingJürgen Gallinat
Jan 13, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tao WeiYanchao Bi

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Citations

Apr 24, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Adam TurnbullJonathan Smallwood

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