The structural basis of XRCC1-mediated DNA repair

DNA Repair
Robert E London

Abstract

Scaffold proteins play a central role in DNA repair by recruiting and organizing sets of enzymes required to perform multi-step repair processes. X-ray cross complementing group 1 protein (XRCC1) forms enzyme complexes optimized for single-strand break repair, but participates in other repair pathways as well. Available structural data for XRCC1 interactions is summarized and evaluated in terms of its proposed roles in DNA repair. Mutational approaches related to the abrogation of specific XRCC1 interactions are also discussed. Although substantial progress has been made in elucidating the structural basis for XRCC1 function, the molecular mechanisms of XRCC1 recruitment related to several proposed roles of the XRCC1 DNA repair complex remain undetermined.

References

Feb 11, 1992·Biochemistry·P L PanzeterF R Althaus
Jun 1, 1989·Molecular and Cellular Biology·D ChelskyG Jonak
May 2, 1988·European Journal of Biochemistry·J Wesierska-Gadek, G Sauermann
Jan 1, 1967·Acta Chemica Scandinavica·O Henriksen, M B Jensen
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·J S HoffmannG Villani
Jan 1, 1994·Molecular and Cellular Biology·K W CaldecottL H Thompson
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·W Zhou, P W Doetsch
Aug 22, 1996·Nature·J R NelsonD C Hinkle
Aug 1, 1998·The Journal of Biological Chemistry·T R Waters, P F Swann
Nov 3, 1998·The EMBO Journal·X ZhangP S Freemont
Aug 24, 1999·The Biochemical Journal·D D'AmoursG G Poirier
Mar 14, 2000·Mutation Research·L H Thompson, M G West
Aug 5, 2000·Free Radical Biology & Medicine·R Gopalakrishna, S Jaken
Oct 4, 2000·The Journal of Biological Chemistry·J M PleschkeF R Althaus
Dec 19, 2000·Biochemical and Biophysical Research Communications·K YamaneT Tsuruo
Mar 22, 2001·Biochemistry·M J JezewskaW Bujalowski
Mar 23, 2002·Molecular and Cellular Biology·Richard M TaylorKeith W Caldecott
Oct 22, 2002·The Journal of Biological Chemistry·Laurence ServantJean-Sébastien Hoffmann
Dec 7, 2002·Structure·Michael R GrykGregory P Mullen
Feb 28, 2003·DNA Repair·Yoshiko Kubota, Saburo Horiuchi
Apr 26, 2003·Trends in Biochemical Sciences·Philip J Hogg
May 16, 2003·Molecular and Cellular Biology·Satoshi OkanoAkira Yasui
Jun 26, 2003·Nucleic Acids Research·Leigh WillardDavid S Wishart
Jul 29, 2003·The Journal of Biological Chemistry·Robert W SobolSamuel H Wilson
Aug 5, 2003·BioFactors·Martine Torres, Henry Jay Forman
Aug 23, 2003·The Journal of Biological Chemistry·Stéphanie MarsinJ Pablo Radicella
Sep 12, 2003·DNA Repair·Keith W Caldecott
Sep 23, 2003·Nucleic Acids Research·Sherif F El-KhamisyKeith W Caldecott

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Citations

Jul 28, 2016·Cell Discovery·Mohammad H Al-KhalafLynn A Megeney
May 1, 2016·Methods : a Companion to Methods in Enzymology·Piri WelcshJulia Sidorova
Dec 14, 2016·Nucleic Acids Research·Thomas W KirbyRobert E London
Apr 9, 2018·Biochemistry. Biokhimii︠a︡·N A Moor, O I Lavrik
Dec 1, 2018·Molecular Carcinogenesis·Jiabo DiXiangqian Su
Mar 21, 2019·Radiology and Oncology·Kristina LevpuscekAlenka Franko
Mar 13, 2019·Genes·Guillaume BrysbaertMarc F Lensink
Dec 11, 2019·Human Reproduction Update·Loren MéarFrançois Vialard
Oct 13, 2017·Scientific Reports·Tyler GolatoDavid M Wilson
Mar 5, 2020·Doklady. Biochemistry and Biophysics·I A Vasil'evaO I Lavrik
Jun 21, 2020·International Journal of Molecular Sciences·Vasiliki Panou, Oluf Dimitri Røe
Dec 7, 2019·The Biochemical Journal·Steven CupelloShan Yan
Jun 15, 2019·Current Pharmaceutical Design·Daria V KimDmitry O Zharkov
Jul 10, 2020·International Journal of Environmental Research and Public Health·Bing-Yu NiuZhi-Xiang Zhou
Nov 26, 2016·Journal of Experimental & Clinical Cancer Research : CR·Aniello CerratoAngela Celetti
Oct 1, 2020·Therapeutic Advances in Medical Oncology·Kevin J LeeNatalie R Gassman
Aug 6, 2020·Genes·Anna V YudkinaDmitry O Zharkov
Sep 10, 2020·Brazilian Oral Research·Deborah Gondim Lambert MoreiraRoseana de Almeida Freitas
Apr 29, 2020·PloS One·Veronica Gomez GodinezMichael W Berns
Oct 23, 2020·DNA Repair·Olga I Lavrik
Feb 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chao MeiZhao-Qian Liu
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhiwei ZhangWeifeng Mao
Mar 16, 2021·Journal of Receptor and Signal Transduction Research·Zhangyong YinJiongwei Pan
Jun 3, 2021·International Journal of Molecular Sciences·Boleslaw T Karwowski

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