The structural maintenance of chromosomes (SMC) family of proteins in mammals

Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
A R Ball, Kyoko Yokomori

Abstract

Structural maintenance of chromosomes (SMC) family proteins play critical roles in chromosome structural changes. SMC proteins are known to be involved in two major chromosome structural organization events required for mitotic segregation of chromosomes: mitotic chromosome condensation and sister chromatid cohesion. In eukaryotes, two separate sets of SMC heterodimers form the cores of two distinct multiprotein complexes termed 'condensin' and 'cohesin', each specialized for condensation or cohesion, respectively. It is clear that both condensin and cohesin are conserved in mammals, including humans. The mammalian complexes demonstrate dynamic changes in intracellular distribution in a cell cycle-dependent manner. At any point in the cell cycle, the intracellular localization of the majority of mammalian cohesin and condensin appears to be complementary. Cohesin is associated with chromatin in interphase, while condensin is largely cytoplasmic. Similarly, in mitosis, cohesin is mostly excluded from chromosomes while condensin is distinctly bound to them. Cell cycle-dependent targeting of the two complexes appears to play a major role in regulating their cell cycle-specific activities, and how this redistribution is controlled ...Continue Reading

Citations

May 3, 2002·European Journal of Biochemistry·Pamela B Meluh, Alexander V Strunnikov
Feb 18, 2003·Molecular Biology of the Cell·Marcin R PrzewlokaRobert B Cary
May 31, 2001·Microbiology and Molecular Biology Reviews : MMBR·N Nanninga
Feb 27, 2007·PLoS Genetics·Ana M ValdeolmillosJulio S Rufas
Apr 22, 2016·Cellular and Molecular Life Sciences : CMLS·Sonia YuWen H Shen
May 4, 2002·Molecular and Cellular Endocrinology·Liat Ben-Yehoshua Josefsberg, Nava Dekel

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