The structural neural substrates of persistent negative symptoms in first-episode of non-affective psychosis: a voxel-based morphometry study.

Frontiers in Psychiatry
Audrey BenoitMartin Lepage

Abstract

An important subset of patients with schizophrenia present clinically significant persistent negative symptoms (PNS). Identifying the neural substrates of PNS could help improve our understanding and treatment of these symptoms. This study included 64 non-affective first-episode of psychosis (FEP) patients and 60 healthy controls; 16 patients displayed PNS (i.e., at least one primary negative symptom at moderate or worse severity sustained for at least six consecutive months). Using voxel-based morphometry (VBM), we explored for gray matter differences between PNS and non-PNS patients; patient groups were also compared to controls. All comparisons were performed at p < 0.05, corrected for multiple comparisons. PNS patients had smaller gray matter in the right frontal medial-orbital gyrus (extending into the inferior frontal gyrus) and right parahippocampal gyrus (extending into the fusiform gyrus) compared to non-PNS patients. Compared to controls, PNS patients had smaller gray matter in the right parahippocampal gyrus (extending into the fusiform gyrus and superior temporal gyrus); non-PNS patients showed no significant differences to controls. Neural substrates of PNS are evident in FEP patients. A better understanding of the...Continue Reading

Citations

May 15, 2015·Acta Psychiatrica Scandinavica·B L AmannE Pomarol-Clotet
Mar 31, 2015·Schizophrenia Research·Lynn Mørch-JohnsenIngrid Agartz
May 14, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Mark J MillanWilliam P Horan
Jan 19, 2016·L'Encéphale·A KaladjianJ-M Azorin
Nov 29, 2014·The Australian and New Zealand Journal of Psychiatry·K Oliver SchubertBernhard T Baune
Dec 16, 2017·Clinical EEG and Neuroscience·Maria PontilloStefano Vicari
Mar 24, 2015·European Archives of Psychiatry and Clinical Neuroscience·Silvana GalderisiArmida Mucci
Oct 11, 2019·Schizophrenia Bulletin·Andrea Pelletier-Baldelli, Daphne J Holt
Nov 7, 2019·The Cochrane Database of Systematic Reviews·Dina Bosnjak KuharicLivia Puljak
Sep 2, 2020·International Journal of Environmental Research and Public Health·Tji Tjian CheeRoger Ho
Mar 6, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Martin LepageAshok K Malla
Apr 19, 2021·The Lancet. Psychiatry·Jayson Jeganathan, Michael Breakspear

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Software Mentioned

DARTEL
SPSS
VBM8
VBM

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