The structure and evolution of vertebrate fibrinogen: a comparison of the lamprey and mammalian proteins

Advances in Experimental Medicine and Biology
R F Doolittle

Abstract

The blood plasmas of all vertebrate animals contain a six-chained fibrinogen molecule that is polymerized into fibrin upon the thrombin-catalyzed removal of fibrinopeptides. In all cases, also, the polymerization reaction is inhibited by Gly-Pro-Arg-ending peptides. The complete amino acid sequences of human, rat and lamprey fibrinogens are known, permitting an assessment of just which sequence features are essential for polymerization. To an extent, the same approach can also be applied to the associated phenomena of fibrin cross-linking by factor XIII, plasminogen and plasminogen activator binding, and vessel wall-fibrinogen interactions.

Citations

Apr 1, 1996·Clinical Genetics·R M Lawn
Nov 17, 2005·Proteins·Russell F Doolittle, Justin M Kollman
Jun 14, 2017·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mohamed El-MeserySally Y Abed
Jun 26, 2009·Journal of Thrombosis and Haemostasis : JTH·R F DoolittleD Wilcox
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·J SheehanP Jagadeeswaran
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yong Jiang, Russell F Doolittle
Feb 24, 2021·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mohamed El-MeseryAbdelaziz Elgaml
Nov 5, 2020·ACS Applied Materials & Interfaces·Ekrem OzkanHitesh Handa
Feb 24, 2011·Acta Biomaterialia·Prashant K PurohitJohn W Weisel

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