PMID: 1322748Jun 1, 1992Paper

The structure and function of Na+ channels

Current Opinion in Neurobiology
W Stühmer, A B Parekh

Abstract

The past year has seen major advances in our understanding of voltage-gated ion channels through a powerful combination of patch-clamp and molecular biological techniques. These approaches have identified regions (in some cases single amino acid residues) that are essential for voltage-dependent activation and inactivation, lining of the pore, and regulation of channel function.

References

Jan 1, 1991·The Journal of Membrane Biology·J W Herzig, M Kohlhardt
Jan 1, 1991·Annals of the New York Academy of Sciences·W S AgnewS A Tomiko
Apr 1, 1991·Pflügers Archiv : European journal of physiology·F Lehmann-HornC Franke
Jun 1, 1991·Current Opinion in Neurobiology·W A Catterall
Jan 22, 1991·Proceedings. Biological Sciences·R D Keynes
Jan 1, 1990·Annual Review of Physiology·A M Brown, L Birnbaumer
Jun 1, 1990·Trends in Neurosciences·H R Guy, F Conti
Jan 1, 1991·Annual Review of Biophysics and Biophysical Chemistry·W Stühmer
Feb 22, 1991·Science·H A HartmannA M Brown
Aug 1, 1990·The Journal of General Physiology·L ToroE Stefani
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H R Guy, P Seetharamulu
Jun 1, 1989·The American Journal of Physiology·K OnoM Arita
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P VassilevW A Catterall
Oct 1, 1973·The Journal of General Physiology·C M ArmstrongE Rojas

Citations

Dec 9, 1994·Biochimica Et Biophysica Acta·F Franciolini
Jun 1, 1993·Current Opinion in Neurobiology·A L Goldin
Jul 19, 2002·Neuroscience Letters·T MiyawakiNobuhumi Kawai
Oct 1, 1992·Nature Genetics·J H Caldwell, K L Schaller
Dec 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Paul G DeCaenW A Catterall
Feb 1, 1994·The Journal of General Physiology·T HoshiR W Aldrich
Oct 14, 2000·Annual Review of Cell and Developmental Biology·W A Catterall
Jul 11, 2000·The European Journal of Neuroscience·Y SaharaN Kawai
Jul 3, 1999·Physiological Reviews·A MeirR Rahamimoff

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.