PMID: 9645224Jun 30, 1998Paper

The structure and function of platelet-activating factor acetylhydrolases

Cellular and Molecular Life Sciences : CMLS
Z S Derewenda, U Derewenda

Abstract

Platelet-activating factor acetylhydrolases (PAF-AHs, EC 3.1.1.47) constitute a unique and biologically important family of phospholipase A2s. They are related to neither the well-characterized secretory nor cytosolic PLA2s, and unlike them do not require Ca2+ for catalytic activity. The distinguishing property of PAF-AHs is their unique substrate specificity: they act on the phospholipid platelet-activating factor (PAF), and in some cases on proinflammatory polar phospholipids, from which they remove a short acyl moiety--acetyl in the case of PAF--located at the sn-2 position. Because PAF is found both in the plasma and in the cytosol of many tissues, PAF-acetylhydrolases are equally widely distributed in an animal organism. Recent crystallographic studies shed new light on the complex structure-function relationships in PAF-AHs.

Citations

Jan 10, 2012·Applied Biochemistry and Biotechnology·Frédéric FrancisEric Haubruge
Aug 1, 2014·Expert Opinion on Therapeutic Targets·Eirini NitodaMarilita M Moschos
Aug 29, 2012·Expert Opinion on Therapeutic Targets·Eirini NitodaMichael Koutsilieris
Mar 14, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H Y FangL-S Wang
May 11, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·L M McManus, R N Pinckard
Feb 26, 2019·Proceedings of the National Academy of Sciences of the United States of America·Ana Kasirer-FriedeSanford J Shattil
Jul 1, 2017·Molecular Pharmacology·Yanhua WangXiaolin Wu
Jul 27, 2017·Blood·Simon StrittBernhard Nieswandt

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