The structure and function of the int-2 oncogene

Progress in Growth Factor Research
C DicksonG Peters

Abstract

The classification of int-2 as a growth factor is based primarily on the similarities between the predicted amino acid sequence and that of basic fibroblast growth factor (bFGF), as well as other members of this expanding family of related proteins. In this review, we summarise the background to the identification of int-2 as a proto-oncogene in virally induced mouse mammary tumours and describe key features of the structure and expression of both the mouse and human homologues. The normal sites of int-2 expression include specific embryonic cell types suggesting multiple inductive or morphogenetic roles. Recent progress in the characterisation of the int-2 product will be discussed in relation to the similarities and differences between int-2 and other FGFs.

References

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Citations

Jul 1, 1992·European Journal of Pediatrics·L Schweigerer, T Fotsis
Jan 1, 1990·Progress in Growth Factor Research·W Risau
Jul 1, 1992·European Journal of Cancer. Part B, Oral Oncology·J K Field
May 21, 2003·Breast Cancer Research and Treatment·Christopher J OrmandyRobert L Sutherland
Oct 1, 1991·The Journal of Cell Biology·F Fuller-PaceC Dickson
Jan 1, 1991·Annals of the New York Academy of Sciences·C DicksonG Peters
Nov 30, 1993·Annals of the New York Academy of Sciences·J Taylor-PapadimitriouF Berdichevsky
Dec 1, 1991·Baillière's Clinical Endocrinology and Metabolism·C Ponzetto
Apr 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V FantlD M Barnes
Mar 22, 2000·DNA Sequence : the Journal of DNA Sequencing and Mapping·S DjenabiC Lavialle
Nov 22, 1991·Science·S A Aaronson

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