The structure-function relationship of the enterovirus 3'-UTR

Virus Research
Jan ZollWillem J G Melchers

Abstract

Essential processes in living cells are carried out by large complex assemblies, which typically consist of a large number of proteins and frequently also contain nucleic acids, mostly RNA [Alberts, B., 1998. The cell as a collection of protein machines: preparing the next generation of molecular biologists. Cell 92, 291-294]. These large biomolecular complexes carry out biological processes in highly sophisticated ways: molecules do not move around randomly in the cell and interact by chance, but are guided to these "macromolecular machines", in which the number of possible collisions is restricted to a few possibilities, based, e.g., on the specificity of protein-RNA recognition. While the coding capacity of RNA lies within its sequence, the shape of an RNA molecule determines other functionalities such as stability, intra- and intermolecular interactions, catalytic activity, regulation of cellular processes, etc. [Doudna, J.A., 2000. Structural genomics of RNA. Nat. Struct. Biol. 7, 954-956; Cech, T.R. 2000. Structural biology. The ribosome is a ribozyme. Science 289, 878-879]. RNA structures in macromolecular machines are important features in assembly, target recognition and activity. Viral RNA molecules contain cis- and/o...Continue Reading

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Citations

Jan 30, 2009·Journal of Virology·Jan ZollFrank J M van Kuppeveld
Oct 9, 2009·Journal of Virology·Benjamin P Steil, David J Barton
Jul 1, 2011·Journal of Virology·Shin-Ru ShihMei-Ling Li
Sep 22, 2011·PloS One·Jan ZollFrank J M van Kuppeveld
Nov 1, 2011·World Journal of Gastroenterology : WJG·Jing LuMing-Liang He
Aug 18, 2012·Virologica Sinica·Jun JinChunlai Jiang
Dec 6, 2011·Current Opinion in Virology·Sushma A Ogram, James B Flanegan
Feb 10, 2012·Current Opinion in Virology·Lucas C Reineke, Richard E Lloyd
Sep 29, 2009·Biochimica Et Biophysica Acta·Ying LiuAniko V Paul
Aug 29, 2013·Reviews in Medical Virology·Cristina Romero-López, Alfredo Berzal-Herranz
Oct 4, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Akos BorosGábor Reuter
Jun 10, 2016·Scientific Reports·Zichun XiangJianwei Wang
May 12, 2017·Journal of Virology·Pengcheng ShangYing Fang
Nov 1, 2018·Reviews in Medical Virology·Mojtaba RastiAli Teimoori
Mar 16, 2018·Microbiology and Molecular Biology Reviews : MMBR·Vadim I Agol, Anatoly P Gmyl
Jan 23, 2018·Frontiers in Microbiology·Chun Shen Lim, Chris M Brown
Mar 11, 2020·Frontiers in Microbiology·Bo-Shiun ChenShin-Ru Shih
Jan 1, 2021·Frontiers in Microbiology·Shao-Hua WangJuan Du
Aug 24, 2021·The Journal of General Virology·Maureen H V FernandesDiego G Diel
Nov 25, 2011·RNA·Amanda Y KeelJeffrey S Kieft

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