The Structure of a Conserved Telomeric Region Associated with Variant Antigen Loci in the Blood Parasite Trypanosoma congolense.

Genome Biology and Evolution
Ali Hadi AbbasAndrew P Jackson

Abstract

African trypanosomiasis is a vector-borne disease of humans and livestock caused by African trypanosomes (Trypanosoma spp.). Survival in the vertebrate bloodstream depends on antigenic variation of Variant Surface Glycoproteins (VSGs) coating the parasite surface. In T. brucei, a model for antigenic variation, monoallelic VSG expression originates from dedicated VSG expression sites (VES). Trypanosoma brucei VES have a conserved structure consisting of a telomeric VSG locus downstream of unique, repeat sequences, and an independent promoter. Additional protein-coding sequences, known as "Expression Site Associated Genes (ESAGs)", are also often present and are implicated in diverse, bloodstream-stage functions. Trypanosoma congolense is a related veterinary pathogen, also displaying VSG-mediated antigenic variation. A T. congolense VES has not been described, making it unclear if regulation of VSG expression is conserved between species. Here, we describe a conserved telomeric region associated with VSG loci from long-read DNA sequencing of two T. congolense strains, which consists of a distal repeat, conserved noncoding elements and other genes besides the VSG; although these are not orthologous to T. brucei ESAGs. Most conser...Continue Reading

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Citations

May 1, 2019·Parasites & Vectors·Mathieu CaylaKeith R Matthews
Apr 4, 2019·PLoS Neglected Tropical Diseases·Siddharth JayaramanLiam J Morrison
Oct 30, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·James D Bangs
Sep 9, 2019·GigaScience·Sara Silva PereiraAndrew P Jackson
Aug 12, 2021·Trends in Parasitology·Sara Silva PereiraLuísa M Figueiredo
Aug 5, 2021·Annual Review of Microbiology·Keith R Matthews

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Datasets Mentioned

BETA
NHO00000000

Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

Hierarchical Genome Assembly Process 3 ( HGAP3 )
HGAP3
Artemis
Phi
RaxML
PHYML
MUSCLE
Topali
Companion
tBLASTx

Related Concepts

Related Feeds

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.