The structure of beta-lactamases

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
R P Ambler

Abstract

The beta-lactamases are widely distributed in both Gram-positive and Gram-negative bacteria. They all inactivate penicillins and cephalosporins by opening the beta-lactam ring. Many varieties of the enzyme can be distinguished on the basis of their catalytic and molecular properties, but only amino acid sequence determination gives information upon which a molecular phylogeny can be based. The present evidence suggests that the beta-lactamases have a polyphyletic origin. All the beta-lactamases of currently known amino acid sequence belong to one homology group, here called class A enzymes. Class B consists of the mechanistically distinct Bacillus cereus beta-lactamase II, which preliminary partial sequence analysis suggests to be structurally unrelated to the class A enzymes. It is predicted that sequence analysis will show that further classes will need to be created to account for particular beta-lactamases of distinctive molecular and mechanistic properties.

Citations

Feb 1, 1987·Molecular & General Genetics : MGG·R C LevesqueG A Jacoby
May 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M T Nüesch-InderbinenF H Kayser
Oct 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M V HayesS G Amyes
Jan 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A PhilipponP H Lagrange
Apr 24, 1999·Applied Biochemistry and Biotechnology·B AvalleA Friboulet
Jul 1, 1989·Diagnostic Microbiology and Infectious Disease·H C Neu
Oct 8, 1999·Pharmacology & Therapeutics·Y YangD M Shlaes
Dec 14, 1999·International Journal of Antimicrobial Agents·K PrabhakaranB Randhawa
May 7, 1999·Bioorganic & Medicinal Chemistry Letters·P BithaY I Lin
Sep 29, 2000·Microbes and Infection·K S Thomson, E Smith Moland
Oct 6, 2007·Biochemistry·Jean-Emmanuel Hugonnet, John S Blanchard
Feb 4, 2010·Journal of Medicinal Chemistry·Peter OelschlaegerJeffrey H Toney
Jul 17, 1999·European Journal of Biochemistry·J Walther-RasmussenN Høiby
Feb 28, 1991·The New England Journal of Medicine·G A Jacoby, G L Archer
Jan 28, 2005·The New England Journal of Medicine·George A Jacoby, Luisa Silvia Munoz-Price
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B Jaurin, T Grundström
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G Dalbadie-McFarlandJ H Richards
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R F Pratt, C P Govardhan
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·F LindbergS Normark
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M OuelletteP H Roy
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A R Oliphant, K Struhl
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Y H ChangJ H Richards
Dec 5, 2012·The Journal of Biological Chemistry·Song SunDan I Andersson
Jan 1, 1985·Biotechnology & Genetic Engineering Reviews·A Coulson
Aug 9, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louis B Rice
Jul 1, 1996·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·M Hernandez VilladaresG Amicosante
Sep 5, 2009·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Nahed Ben AchourOmrane Belhadj
Jun 16, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Latania K Logan
Mar 26, 2009·The Journal of Antimicrobial Chemotherapy·Karen BushAlkiviadis Vatopoulos
Sep 9, 2011·Protein Engineering, Design & Selection : PEDS·Bartlomiej G FryszczynTimothy Palzkill

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