PMID: 6160069Oct 1, 1980Paper

The structure of newly synthesized intracellular thyroglobulin molecules

Molecular and Cellular Endocrinology
G BergR Ekholm

Abstract

Thyroglobulin molecules from normal rats and rats treated with propylthiouracil (PTU) were studied in the electron microscope by the negative staining technique. Intracellular molecules were prepared from exocytotic vesicles, and extracellular molecules from the high-speed centrifugation supernatant. In accord with our previous findings, extracellular thyroglobulin molecules from normal glands had an ovoid conformation, whereas extracellular molecules from PTU-treated glands had a different, cylindrical shape. Thyroglobulin molecules from exocytotic vesicles were of the ovoid variety in normal as well as in PTU-exposed thyroids. Two interpretations are discussed. One would be that PTU exerts a non-physiological effect on ovoid molecules in connection with exocytosis of thyroglobulin. The other interpretation is that thyroglobulin molecules normally undergo 2 transformations (ovoid-cylinder-ovoid) during the process of exocytosis; PTU would inhibit the second transformation and cause accumulation of cylinders in the colloid.

References

Jun 1, 1976·Molecular and Cellular Endocrinology·U BjörkmanT Ofverholm
Apr 29, 1975·Biochimica Et Biophysica Acta·G Berg, R Ekholm
Feb 1, 1973·Journal of Ultrastructure Research·G Berg
Nov 1, 1973·Journal of Ultrastructure Research·U Bjórkman, R Ekholm
May 25, 1966·Biochemical and Biophysical Research Communications·S LissitzkyJ Torresani
Mar 1, 1980·Molecular and Cellular Endocrinology·G BergR Ekholm

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Citations

Apr 1, 1981·Molecular and Cellular Endocrinology·L E Ericson
Jul 1, 1985·Molecular and Cellular Endocrinology·Y KondoN Ui
Jun 1, 1988·Molecular and Cellular Endocrinology·Y KondoS Ohtaki
Nov 26, 2015·Endocrine Reviews·Bruno Di Jeso, Peter Arvan
Aug 1, 1983·Journal of Endocrinological Investigation·L E Ericson
Feb 7, 2020·Nature·Francesca CosciaJan Löwe
May 9, 2021·Molecular and Cellular Endocrinology·Francesca Coscia, Ajda Taler-Verčič

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