PMID: 737171Dec 19, 1978Paper

The structure of oriented sphingomyelin bilayers

Biochimica Et Biophysica Acta
R S Khare, C R Worthington

Abstract

X-ray diffraction from oriented bilayers of sphingomyelin gave up to 14 orders of diffraction of a lamellar repeat of 68.5 A on the merididan and up to eight reflections, including a strong reflection at 4.2 A, on the equator. The diffraction spacings did not change when the sphingomyelin bilayers were exposed to different humidities. A direct analysis of the low resolution X-ray data, using deconvolution is presented. A comparison of the Patterson functions of sphingomyelin with those of phosphatidylcholine and phosphatidylethanolamine suggests that the molecular structure of sphingomyelin in oriented bilayers resembles the structure of both phosphatidylcholine and phosphatidylethanolamine. Molecular model calculations for sphingomyelin bilayers have also been performed. Electron density profiles of sphingomyelin bilayers at resolution of about 6 A and about 2.5 A are presented. Our results indicate that the phosphorylcholine head group of sphingomyelin is in the plane of the membrane and at right angles to the hydrocarbon chains, the hydrocarbon chains are nearly parallel to each other, and there is only a limited, if any, interdigitation of the hydrocarbon chains of the adjacent sphingomyelin molecules in the bilayer.

References

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Citations

Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D L DorsetF Zemlin
Aug 12, 1982·Biochimica Et Biophysica Acta·N S Murthy, C R Worthington
Oct 2, 1987·Biochimica Et Biophysica Acta·D L Dorset, A K Massalski
Oct 13, 2000·Biochimica Et Biophysica Acta·S R Ferguson-YankeyM C Yappert
Oct 13, 2000·Biochimica Et Biophysica Acta·C M TalbottM C Yappert
May 23, 2002·Biophysical Journal·Madalina RujoiM Cecilia Yappert
Jul 20, 1981·Biochimica Et Biophysica Acta·D J Siminovitch, K R Jeffrey
Sep 1, 1987·Journal of Electron Microscopy Technique·D L Dorset
Feb 25, 1992·Biochemistry·T J McIntoshC H Huang
Sep 1, 1988·Chemistry and Physics of Lipids·D L Dorset, W A Pangborn
Sep 18, 1980·Biochimica Et Biophysica Acta·S W HuiP L Yeagle

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