Apr 1, 2020

The target landscape of N4-hydroxycytidine based on its chemical neighborhood

BioRxiv : the Preprint Server for Biology
Jordi Mestres

Abstract

N4-hydroxycytidine (NHC) has been recently reported to have promising antiviral activity against SARS-CoV-2. To join worldwide efforts in identifying potential drug targets against this pandemic, the target landscape of NHC was defined by extracting all known targets of its chemical neighborhood, including drugs, analogues, and metabolites, and by performing target predictions from two independent platforms, following the recent Public Health Assessment via Structural Evaluation (PHASE) protocol. The analysis provides a list of over 30 protein targets that could be useful in future design activities of new COVID-19 antivirals. The relevance for existing drugs within the same chemical space, such as remdesivir, is also discussed.

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Mentioned in this Paper

Theoretical Study
Anatomical Space Structure
Calculi
Calculus (Lab Procedure)
Structure
Simulation
Species
Case-Control Studies
Metric
Protein Expression

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