The structure of the aflatoxin B1-DNA adduct at N7 of guanine. Theoretical intercalation and covalent adduct models

Journal of Biomolecular Structure & Dynamics
M Bonnett, E R Taylor

Abstract

Two theoretical models are proposed for the conformational structure of both intercalated and covalent adduct complexes of aflatoxin B1, designated AFB1, with N7 of guanine of DNA. The covalent adduct model requires the DNA to kink a minimum of 39 degrees about the covalent site of the C8 and N7 atoms comprising the bond of the covalent complex. The preference of AFB1 for specific G bases within a sequence of GC content followed that of experimental studies with the added feature that for binding to the third G base of a tetramer sequence from the 3'-end, the AFB1 displayed enhanced binding at the 3' site of the targeted guanosine. Binding of AFB1 to the second G base of a tetramer sequence from the 3'-end leads to preference for a 5' site of the targeted guanosine. Inhibition of AFB1's interaction with the targeted DNA in the presence of intercalated ethidium bromide is explained by these proposed models.

References

Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A D D'Andrea, W A Haseltine
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J M EssigmannG N Wogan
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·P J BondS J Lippard
Jun 1, 1985·Journal of Biomolecular Structure & Dynamics·K J MillerW J Stevens
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L M RefoloM Z Humayun
Dec 1, 1974·Biopolymers·J M Eyster, E W Prohofsky
Jan 1, 1972·Annual Review of Biophysics and Bioengineering·D A Brant
Aug 16, 1974·Science·D M Jerina, J W Daly
Nov 11, 1967·Nature·R Schoental, S Gibbard
May 1, 1967·The Biochemical Journal·J I Clifford, K R Rees
Jan 1, 1980·Teratogenesis, Carcinogenesis, and Mutagenesis·H AutrupC C Harris
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·K F MuenchM Z Humayun
Jun 30, 1980·Biochemical and Biophysical Research Communications·A KootstraT J Slaga
Jun 1, 1981·Biochemical and Biophysical Research Communications·N E GeacintovR G Harvey
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J D GroopmanG N Wogan
Jul 1, 1981·Mutation Research·A LéonardP Jacquet
Feb 20, 1965·Journal of the American Chemical Society·T ASAOG N WOGAN
Oct 1, 1979·Journal of Food Protection·J W Bennett, L S Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.