The structure of the head-tail junction of the myosin molecule

Journal of Molecular Biology
G Offer, Peter J Knight

Abstract

An atomic model of the junction between the two heads and tail of a myosin molecule has been created by attaching a scallop regulatory domain to the end of each of the two alpha-helical strands of a model of the scallop alpha-helical coiled coil. The C-terminal alpha-helix of the heavy chain of each regulatory domain was superposed over the corresponding sequence in the coiled coil. In the structure created, the two heads lie alongside one another with their bases in contact but remarkably without steric clash. The principal interactions between the two heads are between the regulatory light chains and there are also head-tail interactions between each regulatory light chain and its heavy chain partner in the coiled coil. The invariant proline residues cause the heavy chains to flare to form the fork. The direction of the turn at the WQW sequence within the regulatory domain causes the long alpha-helix of the heavy chains within the head to continue the sense of the supercoil. With the bases of heads interacting, motion of the heads could still occur by a flexing of the coiled coil close to the heads and by a flexing and twisting of the long alpha-helices in the head. The model accounts for some of the conserved sequence featur...Continue Reading

Citations

Apr 24, 1999·European Journal of Biochemistry·A Málnási-CsizmadiaL Nyitray
Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·K M TrybusH L Sweeney
Dec 30, 1999·The Journal of Cell Biology·T WendtK A Taylor
Feb 6, 1998·Journal of Molecular Biology·R PadrónR Craig
Jan 13, 2006·European Biophysics Journal : EBJ·Vian AzzuJustin E Molloy
Oct 24, 2019·Journal of Muscle Research and Cell Motility·Pauline BennettK W Ranatunga
Nov 26, 2002·The Journal of Biological Chemistry·Jan L WahlstromChristine R Cremo
Dec 6, 2002·The Journal of Biological Chemistry·Samantha P HarrisJill Trewhella
Mar 27, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Malin PerssonMartina Balaz
Apr 15, 2000·Journal of Molecular Biology·G OfferR Padrón
Dec 5, 1998·Biochemical and Biophysical Research Communications·A Málnási-CsizmadiaL Nyitray
Aug 21, 2007·Journal of Molecular Biology·Stan A BurgessPeter J Knight

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