Aug 10, 1976

The structure of the ventral nerve cord of Caenorhabditis elegans

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
J G WhiteS Brenner


The nervous system of Caenorhabditis elegans is arranged as a series of fibre bundles which run along internal hypodermal ridges. Most of the sensory integration takes place in a ring of nerve fibres which is wrapped round the pharynx in the head. The body muscles in the head are innervated by motor neurones in this nerve ring while those in the lower part of the body are innervated by a set of motor neurones in a longitudinal fibre bundle which joins the nerve ring, the ventral cord. These motor neurones can be put into five classes on the basis of their morphology and synaptic input. At any one point along the cord only one member from each class has neuromuscular junctions. Members of a given class are arranged in a regular linear sequence in the cord and have non-overlapping fields of motor synaptic activity, the transition between fields of adjacent neurones being sharp and well defined. Members of a given class form gap junctions with neighbouring members of the same class but never to motor neurones of another class. Three of the motor neurone classes receive their synaptic input from a set of interneurones coming from the nerve ring. These interneurones can in turn be grouped into four classes and each of three motor n...Continue Reading

  • References13
  • Citations291


  • References13
  • Citations291


Mentioned in this Paper

Caenorhabditis elegans
Nerve Fibers
Motor Neurons
Sensory Integration
Neural Pathways
Electron Microscopy

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