The Structure-To-Function Relationships of Gammaherpesvirus-Encoded Long Non-Coding RNAs and Their Contributions to Viral Pathogenesis

Non-coding RNA
Gabriela Chavez-CalvilloJoanna Sztuba-Solinska


Advances in next-generation sequencing have facilitated the discovery of a multitude of long non-coding RNAs (lncRNAs) with pleiotropic functions in cellular processes, disease, and viral pathogenesis. It came as no surprise when viruses were also revealed to transcribe their own lncRNAs. Among them, gammaherpesviruses, one of the three subfamilies of the Herpesviridae, code their largest number. These structurally and functionally intricate non-coding (nc) transcripts modulate cellular and viral gene expression to maintain viral latency or prompt lytic reactivation. These lncRNAs allow for the virus to escape cytosolic surveillance, sequester, and re-localize essential cellular factors and modulate the cell cycle and proliferation. Some viral lncRNAs act as "messenger molecules", transferring information about viral infection to neighboring cells. This broad range of lncRNA functions is achieved through lncRNA structure-mediated interactions with effector molecules of viral and host origin, including other RNAs, proteins and DNAs. In this review, we discuss examples of gammaherpesvirus-encoded lncRNAs, emphasize their unique structural attributes, and link them to viral life cycle, pathogenesis, and disease progression. We wil...Continue Reading


Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·V E MyerJ A Steitz
Aug 1, 1992·Journal of Virology·J C AlbrechtB Fleckenstein
Aug 26, 1988·Cell·S I LeeJ A Steitz
Nov 15, 1970·International Journal of Cancer. Journal International Du Cancer·B JohanssonG Henle
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M R LernerJ A Steitz
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·D P ToczyskiJ A Steitz
Nov 1, 1995·Trends in Biochemical Sciences·C Y Chen, A B Shyu
Jul 24, 2002·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Christian GilbertGuy Boivin
Sep 24, 2004·Reviews in Medical Virology·Tatsuya TsurumiAyumi Kudoh
Mar 31, 2005·Advances in Cancer Research·Armin Ensser, Bernhard Fleckenstein
Jul 30, 2005·Journal of Virology·Jill BechtelDon Ganem
Apr 12, 2007·Nucleic Acids Research·Lisa J SchererJohn J Rossi
Apr 19, 2007·PLoS Biology·Máximo Ibo GalindoJuan Pablo Couso
May 19, 2007·Science·Philipp KapranovThomas R Gingeras
Jul 10, 2007·Journal of Molecular Biology·Sean A McKennaJoseph D Puglisi
Oct 13, 2007·Cell Death and Differentiation·M IeroL Rivoltini
Dec 2, 2008·PLoS Computational Biology·Marcel E DingerJohn S Mattick
Dec 18, 2008·Nature Immunology·Hisashi Iizasa, Kazuko Nishikura
Jul 4, 2009·The Journal of Biological Chemistry·Irene K Guttilla, Bruce A White
Jul 23, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ronen Ben-AmiYehuda Carmeli
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Colin G CristMargaret Buckingham
Sep 22, 2009·Nature Chemical Biology·Jerod ParsonsThomas Hermann
Jan 19, 2010·Nature Biotechnology·Sean C SempleMichael J Hope
Jun 19, 2010·Science·Demián CazallaJoan Steitz
Aug 2, 2011·Biochimie·Marcel E DingerJohn S Mattick

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antisense oligonucleotide
antisense purification

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