The structures of fluostatins C, D and E, novel members of the fluostatin family

The Journal of Antibiotics
Kathrin SchneiderRoderich D Süssmuth

Abstract

Three new fluostatin antibiotics have been isolated from the culture filtrate of Streptomyces strain Acta 1383. The chemical structures of these compounds were determined by mass spectrometry and NMR spectroscopy. The relative configuration has been determined by X-ray crystal structure analysis and the absolute configuration was deduced from NMR data with the help of Helmchen esters. These compounds represent the first reported epoxide fluostatins (1, 2) and underline previously found analogies to the group of kinamycin antibiotics.

References

Jan 1, 1995·Acta Crystallographica. Section A, Foundations of Crystallography·R H Blessing
Jul 1, 1994·Journal of Clinical Pathology·A J Larner, J Larner
Feb 20, 2002·Chemical Reviews·Steven J. Gould
Aug 4, 2006·The Journal of Antibiotics·Stefanie BaurHans-Peter Fiedler

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Citations

Aug 4, 2006·The Journal of Antibiotics·Stefanie BaurHans-Peter Fiedler
Mar 27, 2015·Chemistry : a European Journal·Faiz Ahmed KhanChava Sudheer
Feb 8, 2008·Journal of the American Chemical Society·Maolin Yu, Samuel J Danishefsky
Nov 10, 2012·Journal of Natural Products·Wenjun ZhangChangsheng Zhang

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