PMID: 6411796Sep 1, 1983Paper

The structuring of an allergy index based on IgE-mediated skin sensitivity to common environmental allergens

The Journal of Allergy and Clinical Immunology
L R FreidhoffR Hussain

Abstract

We computed skin-test sensitivity levels in 485 adults puncture-tested with eight standardized, high-quality inhalant allergens tested at single concentrations. In order to quantitate the "average" IgE-mediated skin sensitivity of each subject, we used both nonparametric and parametric statistical methods to generate two "allergy indices" (Allergy Index I and Allergy Index II) based on sensitivity end-point data from the subpopulations of individuals positive to six of the eight allergens. For the 192 skin test-positive subjects, Allergy Index I and Allergy Index II were significantly correlated with each other (rs = 0.98, p less than 0.001) and with the number of positive skin-test reactions (rs congruent to 0.9, p less than 0.001) as well as with log[total serum IgE] (r congruent to 0.4, p less than 0.01). In 102 ragweed-positive subjects, log[specific IgE to ragweed] was significantly correlated with ragweed-specific "ragweed indices I and II" (r congruent to 0.6, p less than 0.01). Furthermore, the average daily symptom scores reported by 14 ragweed-positive subjects during the ragweed pollination season were significantly correlated with ragweed indices I and II (p less than 0.05). We propose the use of Allergy Index II in...Continue Reading

References

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Citations

Jul 1, 1990·The Journal of Allergy and Clinical Immunology·P A EgglestonM Corn
Sep 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G HedlinN F Adkinson
Aug 1, 1992·Allergy·N R Niemeijer, J G de Monchy
Nov 14, 1997·American Journal of Respiratory and Critical Care Medicine·F KauffmannJ Feingold
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·I M NdukwuA R Leff
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·E T NaureckasJ Solway
Sep 11, 2008·Allergy·C Rolinck-WerninghausUNKNOWN Omalizumab Rhinitis Study Group
Jan 1, 1984·The Journal of Allergy and Clinical Immunology·D F GraftM D Valentine

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