The study of acoustic startle reflex in male patients with chronic schizophrenia

Asian Journal of Psychiatry
Zhiren WangDong Feng Zhou

Abstract

To explore the deficits of acoustic startle reflex (ASR) that might exist in Chinese patients with schizophrenia and the effects of antipsychotics on ASR. Participants included 25 male patients with chronic schizophrenia treated with typical antipsychotics (typical group), 25 who were treated with atypical antipsychotic clozapine (clozapine group) and 25 healthy male subjects (control group) matched for age and years of education. Startle reflex to acoustic stimuli were examined in all subjects from the three groups. At the same day of startle testing, psychopathological symptoms of the patients were assessed with the Positive and Negative Syndrome Scale (PANSS). (1) Startle response (SR) was significantly reduced in typical group as compared to control group [(553.6±516.9)mV vs. (942.0±447.3)mV, P=0.009]. SR of clozapine group [(755.9±439.4)mV] was greater than that of typical group and less than that of control group, but there was no significant difference between the clozapine group and the other two. (2) Habituation (HAB) of startle reflex in typical group was significantly lower than in control group [(17.8±35.8)% vs. (44.9±28.9)%, P=0.027]. HAB of clozapine group [(22.9±34.1)%] was higher than that of typical group and l...Continue Reading

References

Mar 1, 1992·Archives of General Psychiatry·D L BraffM A Geyer
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