PMID: 12768707May 29, 2003Paper

The study of human papilloma viruses infection in juvenile pharynlaryngeal papillomatosis by PCR and dot blot hybridization

Zhonghua er bi yan hou ke za zhi
B ChenH Zhang

Abstract

To study the relationship between infection of human papillomavirus and juvenile pharynlaryngeal papilloma. Polymerase chain reaction (PCR) and dot blot hybridization were used to detect HPV6,11,16,18,33 DNA of 35 samples of pharynlaryngeal papilloma and 10 samples of vocal nodule. The positive rate of HPV in pharynlaryngeal papilloma was 91.4% (30/35). Among them the positive rates of HPV6 and HPV11 were 54.2%(19/35) and 25.7%(9/35), the positive rate of multiple types of HPV6 + 11 was 11.4%(4/35). The positive rate of HPV16,18,33 was negative. The positive rate of HPV in vocal nodule was negative and were significantly different from that of the pharynlaryngeal papilloma group. The results suggest that infection with HPV, especially with HPV6, is closely associated with the development of juvenile pharynlaryngeal papilloma in Wenzhou area. HPV-DNA detected by PCR and dot blot hybridization has highly specificity and sensitivity.

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