PMID: 11902813Mar 21, 2002Paper

The study on organic nitrates, part V. New derivatives of piperazine potential NO donors

The Journal of Pharmacy and Pharmacology
Lucyna Korzycka

Abstract

We have obtained a series of non-symmetrical 1,4-disubstituted derivatives of piperazine, with the structure of organic nitrates, as potential NO donors. These compounds were obtained from respective hydroxyl derivatives of piperazine in an esterification reaction by fuming nitric acid. The obtained nitrates were tested in-vitro by reaction with a sulfhydryl compound. The structure of the most active nitrate and its hydroxyl analogue was used for the calculation of geometrical optimization with the determination of 3D-QSAR by a semi-empirical method PM3 using HyperChem 4.5.

References

Aug 1, 1991·European Journal of Clinical Investigation·S Moncada, E A Higgs

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Citations

Feb 9, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Barbara KostkaLucyna Korzycka
Jul 19, 2005·Expert Opinion on Investigational Drugs·Roberto ScatenaBruno Giardina
Apr 18, 2008·The Journal of Pharmacy and Pharmacology·Lucyna Korzycka, Dorota Górska
Jul 18, 2018·European Journal of Pharmacology·Paolo FagoneFerdinando Nicoletti

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