The subcellular distribution and levels of calmodulin in jejunal biopsies from control subjects and patients with coeliac disease

Clinica Chimica Acta; International Journal of Clinical Chemistry
A J MacphersonT J Peters

Abstract

A radioimmunoassay has been established and validated for the estimation of calmodulin levels in human peroral jejunal biopsy samples. Total levels were similar in biopsies from control subjects and patients with coeliac disease, both in relapse and remission. The subcellular distribution of calmodulin was determined in biopsy samples from control subjects and a patient with coeliac disease in relapse by rapid single-step analytical subcellular fractionation and immunoassay. In both situations most (greater than 70%) of the calmodulin was recovered in the cytosolic fractions with no selective enrichment in any single organelle.

References

Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·C O BrostromD J Wolff
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·D M WattersonT C Vanaman
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J M MarcumA R Means
Nov 1, 1979·Molecular and Cellular Biochemistry·J F WhitfieldB K Tsang
Apr 30, 1977·British Medical Journal·P E Jones, T J Peters
Aug 1, 1988·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·S GhoshA Villalobo
Dec 1, 1985·Clinical Science·S Mac NeilS Tomlinson
Oct 3, 1970·British Medical Journal·C C Booth
Sep 26, 1970·British Medical Journal·C C Booth
Oct 15, 1984·Experientia·I Valverde, W J Malaisse
May 1, 1984·Clinical Science·S TomlinsonB L Brown
Jan 1, 1980·Annual Review of Biochemistry·C B KleeP G Richman
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J G ChafouleasA R Means
Jan 1, 1982·Diabetologia·S TomlinsonB L Brown
Jan 1, 1982·Annals of the New York Academy of Sciences·A R MeansV Guerriero
Nov 1, 1984·Postgraduate Medical Journal·M Shiner
Feb 1, 1983·The British Journal of Dermatology·P C van de Kerkhof, P E van Erp
Jul 31, 1980·Biochemical and Biophysical Research Communications·A L BoyntonJ P MacManus
May 31, 1979·Nature·A Ilundain, R J Naftalin

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