The subcommissural organ and the development of the posterior commissure

International Review of Cell and Molecular Biology
J M GrondonaM D López-Avalos

Abstract

Growing axons navigate through the developing brain by means of axon guidance molecules. Intermediate targets producing such signal molecules are used as guideposts to find distal targets. Glial, and sometimes neuronal, midline structures represent intermediate targets when axons cross the midline to reach the contralateral hemisphere. The subcommissural organ (SCO), a specialized neuroepithelium located at the dorsal midline underneath the posterior commissure, releases SCO-spondin, a large glycoprotein belonging to the thrombospondin superfamily that shares molecular domains with axonal pathfinding molecules. Several evidences suggest that the SCO could be involved in the development of the PC. First, both structures display a close spatiotemporal relationship. Second, certain mutants lacking an SCO present an abnormal PC. Third, some axonal guidance molecules are expressed by SCO cells. Finally, SCO cells, the Reissner's fiber (the aggregated form of SCO-spondin), or synthetic peptides from SCO-spondin affect the neurite outgrowth or neuronal aggregation in vitro.

Citations

Jul 11, 2014·Frontiers in Neuroanatomy·Karen StanicTeresa Caprile
Feb 8, 2016·Brain Structure & Function·Sudheer GiddaluruLars Nyberg
Sep 15, 2020·Frontiers in Psychiatry·Swapna Mahurkar-Joshi, Lin Chang
Dec 28, 2017·Journal of Anatomy·Clemens Kiecker
Jul 13, 2021·Frontiers in Neuroanatomy·Francisco Aboitiz, Juan F Montiel
Oct 4, 2021·Fluids and Barriers of the CNS·Vania SepúlvedaTeresa Caprile

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