May 24, 2020

The subcortical belly of sleep: New possibilities in neuromodulation of basal ganglia?

Sleep Medicine Reviews
Harutomo HasegawaIvana Rosenzweig

Abstract

Early studies posited a relationship between sleep and the basal ganglia, but this relationship has received little attention recently. It is timely to revisit this relationship, given new insights into the functional anatomy of the basal ganglia and the physiology of sleep, which has been made possible by modern techniques such as chemogenetic and optogenetic mapping of neural circuits in rodents and intracranial recording, functional imaging, and a better understanding of human sleep disorders. We discuss the functional anatomy of the basal ganglia, and review evidence implicating their role in sleep. Whilst these studies are in their infancy, we suggest that the basal ganglia may play an integral role in the sleep-wake cycle, specifically by contributing to a thalamo-cortical-basal ganglia oscillatory network in slow-wave sleep which facilitates neural plasticity, and an active state during REM sleep which enables the enactment of cognitive and emotional networks. A better understanding of sleep mechanisms may pave the way for more effective neuromodulation strategies for sleep and basal ganglia disorders.

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Mentioned in this Paper

Sleep Disorders
Anatomic Structures
Emotions
Biological Neural Networks
Sleep Disorders, Circadian Rhythm
Intracranial
Basal Ganglia
Sleep
Neuronal Plasticity
Sleep, REM

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